Hyperlipoproteinemia type V
Introduction
Introduction to hyperlipoproteinemia V Hyperlipoproteinemia type V, also known as fat and sugar-induced hyperlipidemia, high chylomicronemia and high pre-beta-lipoproteinemia, endogenous and exogenous hyperlipidemia, heat Card-induced hyperlipidemia, a hyperlipoproteinemia due to an increase in chylomicrons and VLDLS, is a type of hyperlipoproteinemia type I and type IV. The incidence rate is low, mostly in adulthood. It is considered to be a subtype of type IV and is often associated with obesity and/or alcohol abuse. If the supply of exogenous triglycerides is reduced, it is converted to type IV, and the genetic pattern is similar to type IV. basic knowledge The proportion of sickness: 0.007% Susceptible people: no specific population Mode of infection: non-infectious Complications: hyperuricemia
Cause
Hyperlipoproteinemia type V etiology
(1) Causes of the disease
Hyperlipoproteinemia caused by increased chylomicrons and VLDLS is a combination of type I and type IV of hyperlipoproteinemia.
(two) pathogenesis
Increased endogenous triglyceride synthesis in the liver, as well as exogenous chylomicronemia, decreased lipase levels in some patients.
Prevention
Hyperlipoproteinemia type V prevention
Strict control of calorie intake, keeping weight in the normal range, prohibiting alcohol abuse.
Complication
Hyperlipoproteinemia V-type complications Complications hyperuricemia
In the case where the supply of exogenous triglyceride is reduced, it is converted to type IV. Increased endogenous triglyceride synthesis in the liver, as well as exogenous chylomicronemia, decreased lipase levels in some patients. The skin manifests as rash xanthomas. The incidence of arteriosclerosis is unclear. There may be hepatosplenomegaly, abdominal cramps, hyperuricemia and hyperglycemia. Triglycerides exceeding 1000 mg/dl can cause acute pancreatitis. Patients who do not receive treatment can develop coronary sclerosing heart disease, recurrent pancreatitis.
Symptom
Hyperlipoproteinemia type V symptoms common symptoms abdominal pain hepatosplenomegaly hyperuricemia
The skin manifests as rash xanthomas. The incidence of atherosclerosis is unclear. Hepatosplenomegaly, abdominal cramps, hyperuricemia and hyperglycemia, serum turbidity or milky, and triglycerides continue to increase. While cholesterol levels are normal or slightly higher, VLDLS and chylomicrons are elevated, and glucose tolerance tests and uric acid levels should be measured.
Examine
Hyperlipoproteinemia type V examination
Serum turbidity or milky, triglycerides continue to increase, while cholesterol levels are normal or slightly higher, VLDLS and chylomicrons are increased, glucose tolerance test and uric acid level should be measured.
Diagnosis
Differential diagnosis of hyperlipoproteinemia type V
According to clinical manifestations, the characteristics of skin lesions and the characteristics of serum tests can be diagnosed.
