Hyperlipoproteinemia type III
Introduction
Introduction to type III hyperlipoproteinemia Hyperlipoproteinemia type III is also known as wide beta disease, -lipoproteinemia. It is an independent disease with VLDLS catabolic disorders leading to the accumulation of LDL precursors and intermediates. Lipoprotein electrophoresis suggests LDL mobility, while ultracentrifugation suggests VLDLS. Electrophoretic analysis shows that the broad beta-lipoprotein band, serum cholesterol (up to 1000 mg/ml) and triglycerides (up to 2000 mg/ml) have considerable volatility. The apo-E2/E2 protein phenotype was shown by isoelectric focusing electrophoresis in patients with hyperlipoproteinemia type III. Apo-E2 homozygote is a specific symptom of hyperlipoproteinemia. basic knowledge The proportion of illness: 0.002% Susceptible people: no specific population Mode of infection: non-infectious Complications: hyperuricemia pancreatitis
Cause
Hyperlipoproteinemia type III etiology
(1) Causes of the disease
-lipoprotein is higher in serum than normal-induced conditions.
(two) pathogenesis
VLDLS catabolism causes LDL precursors and intermediates to accumulate, lipoprotein electrophoresis suggests LDL mobility, while ultracentrifugation suggests VLDLS, electrophoretic analysis shows broad beta-lipoprotein bands, serum cholesterol (up to 1000 mg/ml) and glycerol The ester (up to 2000 mg/ml) has considerable volatility, and the apo-E2/E2 protein phenotype is shown by isoelectric focusing electrophoresis in hyperlipoproteinemia type III patients.
Prevention
Hyperlipoproteinemia type III prevention
Correct bad eating habits, properly control the amount of food, and properly reduce weight and control obesity.
Complication
Hyperlipoproteinemia type III complications Complications hyperuricemia pancreatitis
In the case where the supply of exogenous triglyceride is reduced, it is converted to type IV. Increased endogenous triglyceride synthesis in the liver, as well as exogenous chylomicronemia, decreased lipase levels in some patients. The skin manifests as rash xanthomas. The incidence of arteriosclerosis is unclear. There may be hepatosplenomegaly, abdominal cramps, hyperuricemia and hyperglycemia. Triglycerides exceeding 1000 mg/dl can cause acute pancreatitis. Patients who do not receive treatment can develop coronary sclerosing heart disease, recurrent pancreatitis.
Symptom
Hyperlipoproteinemia type III symptoms common symptoms dyslipidemia vascular sclerosis hyperlipidemia vascular damage
Palm linear xanthomas and ring-shaped xanthoma are characteristic features of this disease. The incidence of nodular xanthomas, macular tumors and xanthomas accounts for 20% to 30% of the disease, coronary and/or peripheral vascular lesions. Often occurs, many patients also have recessive diabetes, serum opacity, elevated levels of cholesterol and triglycerides, lipoprotein electrophoresis analysis showed wide beta band, isoelectric focusing electrophoresis showed apo-E2/E2 phenotype.
Examine
Hyperlipoproteinemia type III examination
Serum opacity, elevated levels of cholesterol and triglycerides, lipoprotein electrophoresis showed broad beta band, and isoelectric focusing electrophoresis showed apo-E2/E2 phenotype.
Diagnosis
Diagnosis and diagnosis of type III hyperlipoproteinemia
According to clinical manifestations, the characteristics of skin lesions and the characteristics of serum tests can be diagnosed.
