Pulmonary pseudolymphoma
Introduction
Introduction to pulmonary pseudolymphoma Pulmonary pseudo-lymphoma (PL), also known as nodular lymphoid hyperplasia, refers to a local lymphoid proliferative disorder in the lung, usually a single nodule, and is confined to a single lobe. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: coma, blood in the stool
Cause
Cause of pulmonary pseudolymphoma
Cause:
The etiology and pathogenesis of pulmonary pseudolymphoma are still unclear. It is currently considered to be related to abnormal immune response and belongs to autoimmune diseases. In addition, some studies have suggested that the application of the drug phenytoin is related to viral infection.
Pathogenesis :
Pulmonary pseudolymphoma is yellow-brown and has a clear boundary with surrounding tissues. Fibrosis in the lesion can cause tissue to contract to the center of the mass. The main features of microscopic examination are the heterogeneity of cell components and different changes in different fields of view. Russell The body and germinal center can be very prominent. The infiltrating cells mainly include lymphocytes, plasma cells, occasionally epithelioid tissue cells, and form granulomas. Giant cells are seen in about 1/3 of patients, and there are variability scars. Appearance can be scars of cells and fibroblasts, or cell-free transparent scars, amyloid and non-congo red amyloids can be found, and no monomorphic features conferring lymphocytic lymphoma can be found at the edge of the lesion. Necrosis can be seen in the traces of lymphocyte aggregation.
Prevention
Pulmonary pseudo lymphoma prevention
Abnormal immune function, autoimmune diseases, long-term use of immunosuppressive drugs after organ transplantation, and aging are likely to be important reasons for the significant increase in the incidence of lymphoma in recent years. Physical factors such as radiation, insecticides, herbicides, hair dyes, heavy metals, benzene, and chemicals may also be associated with the onset of lymphoma. Lymphomas have not been found to have a very pronounced genetic predisposition and family aggregation.
Complication
Pulmonary pseudolymphoma complications Complications, coma and blood in the stool
Such conditions can have persistent fever, punctiform hemorrhage, hepatosplenomegaly, bone pain, shortness of breath, coma, severe pain, cough, cough, fever, vomiting, blood in the stool, fatigue, pain, sepsis, nosebleeds, nausea, tinnitus The problem of hepatomegaly, hyperuricemia, and loose bones is the accompanying occurrence of lung diseases. Pay attention to the diseases of the respiratory tract.
Symptom
Pulmonary pseudolymphoma symptoms Common symptoms Chest pain
A small number of patients have a history of pneumonia in the lesion, most patients have no clinical symptoms, or only mild cough and chest pain, usually found in the X-ray examination of the lungs, the general course of disease is longer, there are reports, no change after several years of diagnosis .
Since the disease is only a pathological diagnosis of the disease, it is necessary to rely on biopsy specimens for diagnosis.
Examine
Examination of pulmonary pseudolymphoma
1. Immunoglobulin: hypergammaglobulinemia.
2. Pathological examination: biopsy specimens are usually obtained during thoracotomy. Microscopically, there are obvious mixed cell infiltration and different degrees of fibrosis, and the histological performance is different in different visual fields, but there is obvious tendency of central healing (scarring). Occasionally see granuloma.
3, chest X-ray examination: showing a single nodule or infiltration of the lung into a localized consolidation, the edge is clear, there is bronchial aeration, and the hilar and mediastinal lymph nodes are rare; but the emergence of lymph nodes often increase the malignant disease Possibility, visceral pleura is often found in surgical resection, but pleural effusion is rarely seen on the chest radiograph, and immunolabeling shows polytype staining.
Diagnosis
Diagnosis and diagnosis of pseudo-lymphoma of the lung
diagnosis:
Since the disease is only a pathological diagnosis of the disease, it is necessary to rely on biopsy specimens for diagnosis.
Differential diagnosis:
Pseudolymphoma is difficult to distinguish from low-grade lymphoma and must be supported by complementary techniques such as immunophenotyping and gene rearrangement.
