Transient acantholytic skin disease
Introduction
Introduction to transient echinoderma lysis Transientacantholyticdermatosis, also known as Grover disease (Groverdisease), is apopular acupuncture (popularacantholysis), first reported by Grover in 1970, is a spontaneously relieved adult acanthosis Solve and treat dysplastic diseases. basic knowledge The proportion of sickness: 0.003%-0.007% Susceptible people: no special people Mode of infection: non-infectious Complications: pruritus
Cause
Transient acanthosis to resolve the cause of skin diseases
(1) Causes of the disease
The cause is unknown. There is no evidence related to heredity in this disease, and there are no reports related to infection factors. These patients often have sebum deficiency and there is no other relevant content.
(two) pathogenesis
The pathogenesis is still unclear, and there are no other relevant descriptions at present.
Prevention
Transient acanthosis to prevent skin disease
The disease is often relieved within weeks to months, sometimes in older patients for a longer period of time, usually lasting about 2 months, and individual cases can last for several years.
Complication
Transient acanthosis to resolve skin disease complications Complications pruritus
There are usually no special complications.
Symptom
Transient acanthosis to relieve skin disease symptoms Common symptoms Itching papules Skin blisters or bullae damage scarring
The skin lesions are diffusely distributed in the trunk area, which occurs in the chest, shoulder area and upper abdomen. It can also occur in the rubbing area and limbs. It is loose and easy to break the blisters, and quickly forms scars, sometimes forming keratinized damage, usually 1cm. The size can also be seen in the exudative papules, the surface is smooth or crusted. In short, the skin lesions are various in shape, and the damage is sometimes arranged in groups, and the symptoms are markedly itchy.
Some patients may have elevated levels of eosinophils and serum IgE, and acantholytic cells may be seen on the cell smear.
The disease is often relieved within weeks to months, sometimes in older patients for a longer period of time, so-called persistent or popular acantholytic dermatosis sun exposure can stimulate the disease It usually lasts for about 2 months and individual cases can last for several years.
Examine
Transient acanthosis to resolve skin disease
Histopathology: characterized by the release of blisters in the epidermis, the blisters are located under the horn layer or on the basal cell layer, sometimes accompanied by sponge formation, epidermal cell reticular degeneration and keratosis, histological manifestations of Daryl Disease (Darier disease), characteristic of family-like benign chronic pemphigus (Hailey-Hailey disease), pemphigus vulgaris or deciduous pemphigus and sponge-forming acantholytic dermatitis.
Immunopathology: Both direct immunofluorescence and indirect immunofluorescence were negative.
Diagnosis
Diagnosis and identification of transient echinodermolytic skin disease
Mainly rely on the exclusion of other possible diseases, combined with the age of clinical onset, skin lesions are polymorphic, severe itching, histopathological changes have acanthosis, negative immunofluorescence can help diagnosis.
The differential diagnosis should be differentiated from subacute simple pruritus, ascariasis, sputum, folliculitis, follicular eczema, red millet rash, etc. When the lesion is confined to the trunk, there is obvious itching, and for the elderly, it should be considered Herpes-like dermatitis is identified.
