subcutaneous T-cell lymphoma
Introduction
Introduction to subcutaneous T-cell lymphoma The cause of sudcutaneous panniculitis-like T-celllymphoma is still unclear. Subcutaneous nodules appear in the lower extremities of the patient, often diagnosed as nodular erythema or other types of panniculitis, common erythropoiesis syndrome, and often cause death. basic knowledge The proportion of illness: the incidence rate is about 0.006% - 0.009% Susceptible people: no special people Mode of infection: non-infectious complication:
Cause
The cause of subcutaneous T-cell lymphoma
(1) Causes of the disease
The cause is not yet clear.
(two) pathogenesis
The pathogenesis is still unclear.
Prevention
Subcutaneous T-cell lymphoma prevention
Mainly for the prevention of various factors that may lead to malignant lymphoma. It is currently believed that the loss of normal immune surveillance function, the tumorigenic effect of immunosuppressants, the activity of latent viruses and the long-term application of certain physical (such as radiation), chemical (such as anti-epileptic drugs, adrenocortical hormone) substances, Lead to the proliferation of lymphatic network, and eventually malignant lymphoma. Therefore, pay attention to personal and environmental hygiene, avoid drug abuse, and pay attention to personal protection when working in a harmful environment.
Complication
Subcutaneous T-cell lymphoma complications Complication
The disease is a malignant tumor, often metastasized through the blood circulation system, often accompanied by red blood cell syndrome. It is a multi-organ, multi-system involving, progressively aggravated macrophage proliferative disorder with immune dysfunction, representing a group of diseases with different pathogens, characterized by fever, hepatosplenomegaly, and complete blood cell reduction. Similar to leukemia and aplastic anemia, it is necessary to check the bone penetration.
Symptom
Subcutaneous T-cell lymphoma symptoms Common symptoms Red blood cell syndrome, sintering, meningitis, fatigue, weight loss
Subcutaneous nodules appear in the lower extremities, often diagnosed as nodular erythema or other types of panniculitis, with weight loss, fever and fatigue, common erythroblast syndrome, and often cause death, even in the case of death, outside the skin The affected person is rare, and the disease has a poor prognosis.
Examine
Examination of subcutaneous T-cell lymphoma
Histopathology: The lobular cells of the fat cells have a lamellar infiltration, resembling a panniculitis. The infiltrating cells are composed of small and large lymphoid cells. The cells are atypical, with nuclear fragmentation, mitotic figures are common, and large or small benign tissues can be seen. Cells and can be proven to phagocytose red blood cells.
Immunohistochemistry: Tumor cells are labeled with T cells (CD2, CD3), usually CD4 and CD30.
Diagnosis
Diagnosis and diagnosis of subcutaneous T-cell lymphoma
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
It should be differentiated from phagocytic tissue cell panniculitis and nodular erythema.
