Prurigo nodularis
Introduction
Introduction to nodular pruritus Pseudogonodularis, also known as lichennodularis, is a chronic skin disease characterized by itchy nodules, more common in adult women. This disease is similar to the "Ma Lan" recorded in the medical literature of the motherland. For example, "Theories of the Causes of Diseases" are recorded: "The horses are the roots of the horses, and the skin is hidden from the roots. The doctors know that the disease is "uncoagulation and aggregation." basic knowledge The proportion of sickness: women are relatively common, the overall incidence rate is about 0.01% - 0.02% Susceptible people: no special people Mode of infection: non-infectious Complications: Eczema
Cause
Cause of nodular pruritus
(1) Causes of the disease
The cause is still unclear, and insects (including mosquitoes, cockroaches, bed bugs, etc.: and water bites, scratching, friction, genetic quality, endocrine disorders, gastrointestinal disorders and other factors, some people think that this disease is localized neurodermatitis a variant,
(two) pathogenesis
The pathogenesis is hyperkeratotic, the acanthosis is hypertrophy, the epidermal process is irregularly hyperplasia, forming pseudoepithelial neoplasia; dermal vasodilation, edema, lymphocytes around the blood vessels, tissue cells, plasma cells, mast cells and eosinophils infiltration There is a hardening phenomenon formed by thick connective tissue between the epidermis and the dermis; there is obvious neuronal hyperplasia at the edge or center of the nodule.
Prevention
Nodular pruritus prevention
The most fundamental method of prevention is to do a good job in environmental sanitation and actively eliminate various pests. It is the most active and effective measure to prevent insect bites.
Complication
Nodular pruritus complications Complications eczema
Do not over-scratch to avoid infection and disease.
Symptom
Nodular pruritus symptoms Common symptoms Nodular tension pustule scaly summer pruritus
1. Good for adult women.
2. After a slow period, it can be extended for many years.
3. Occurs on the extremities of the extremities and the back of the hands and feet. It can also be seen in the waist, arms and other parts of the limbs.
4. The primary rash is isolated, scattered, incompatible with the normal skin color of the yellow bean to cherry, brown or dark brown hard and dry hemispherical nodules, the surface is smooth, covered with gray scales that are not easily peeled off, never formed during the process. Blisters, pustules, and no eczema changes. In severe cases, they may be sputum-like, and the surrounding pigmentation may be deepened, which may be followed by lichenification.
5. Paroxysmal itching, especially at night or when the mood is tense.
Examine
Nodular pruritus examination
Visual inspection result
It is a reddish papule, which quickly becomes a hemispherical nodule. The size of soybeans to broad beans is obvious. The apex of the apex is obvious. It has a scorpion-like appearance, rough surface, reddish brown or taupe, scattered in isolation, and has a firm feeling. Exfoliation, hemorrhage and blood stasis occur due to severe scratching. The skin around the nodule is pigmented or thickened and changes like a moss. Nodules occur in the limbs, especially in the calf extension, which can occur on the back. The number varies from as few as several or more to tens of or more, sometimes in stripes. Chronic, can not heal for a long time.
Diagnosis
Diagnosis and diagnosis of nodular pruritus
According to the hemispherical itchy nodules that occur on the extremities of the extremities, the disease can be considered.
Differential diagnosis:
Vermicular lichen
Both can be characterized by itchy sputum lesions, but the verrucous lichen planus is often purple or purplish red, with typical damage visible around or elsewhere.
2. Primary skin amyloidosis
Both can be expressed as nodular lesions in the anterior iliac crest, but amyloidosis occurs in the calf, between the upper arm and the upper back scapula, the skin lesions are brown flat papules, which can be arranged in a bead shape along the skin lines, and the damage is dense and necessary. A biopsy can be done to distinguish.
3. Papular urticaria
Occurs in children, the course of disease is shorter, the lesions are mainly fusiform wheal, with papules, herpes or blisters in the center.
