nodular vasculitis
Introduction
Introduction to nodular vasculitis Nodularvasculitis, also known as skin allergic nodular vasculitis (cuaneousallergicnodularvasculitis) was first described by Montgomery et al., occurring in young adults aged 20 to 40, more women than men, especially standing workers. More common, whether the disease is an independent disease has different views, some scholars believe that only Bazin hard erythema early or light. basic knowledge The proportion of illness: 0.002% Susceptible people: good for young adults aged 20 to 40 Mode of infection: non-infectious Complications: joint pain
Cause
Cause of nodular vasculitis
(1) Causes of the disease
At present, the etiology and pathogenesis are unclear, and may be caused by a variety of factors, such as delayed cutaneous hyperplasia.
Many scholars have applied a lot of research on the humoral immunity and immune complexes of this disease by applying the theory and methods of modern immunology. It is believed that the deposition of immune complexes and complement is closely related to the pathogenesis of vasculitis. Once the circulating immune complex is deposited, In the blood vessel wall, complement can be activated, attracting neutrophils to the site where the immune complex is deposited, releasing enzymes and inflammatory mediators, causing damage to the blood vessel wall, and vascular infarction causes subcutaneous fat necrosis. Therefore, immune complexes, complement, The chain reaction between neutrophils may be an important factor in the pathogenesis of vasculitis. In 1986, Smolle observed the distribution of S-100 dendritic cells in nodular vasculitis lesions, suggesting that nodular vasculitis may be delayed. Caused by the effect of hair style hypersensitivity.
(two) pathogenesis
The pathogenesis is still not very clear. It may be caused by a variety of factors, including cutaneous vasculitis, which is mainly caused by delayed type hypersensitivity. Many scholars believe that the deposition of immune complexes and complement is closely related to the pathogenesis of vasculitis, and circulating immune complexes. Once deposited in the vessel wall, complement can be activated, attracting neutrophils to the site where the immune complex is deposited, releasing enzymes and inflammatory mediators, causing damage to the vessel wall, and vascular infarction causes subcutaneous fat necrosis.
Prevention
Nodular vasculitis prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Nodular vasculitis complications Complications joint pain
joint pain.
Symptom
Nodular vasculitis symptoms Common symptoms Joint pain nodules weakness vasculitis bismuth symmetry occurs plum...
More common in young women, but also in men, male to female ratio of about 1:5, the incidence of obvious seasonality, occurs in the lower limbs, especially the back of the calf, thighs, buttocks and upper arms can also be involved, the lesion is Bright red, dark red and even normal skin color small nodules to larger infiltrating plaques, round or oval, often in the calf, usually similar to the size of broad beans, nodules are hard, the surface of the skin is red hot, there are Spontaneous pain or mild tenderness, disappeared or left with fibrous nodules in about 2 to 4 weeks, and no ulceration occurred. The nodules often recur after a certain period of time and spread to the feet, thighs and upper limbs, but the development is slow. The prognosis is good, sometimes accompanied by joint pain and weakness of the lower limbs, good general condition, and other systems and organs are rarely affected.
Examine
Nodular vasculitis
No special findings, except for the acute phase, erythrocyte sedimentation rate rarely increased, a few cases of ASO, -globulin increased.
Histopathology: moderate arterial wall thickening in the deep dermal and subcutaneous fat layer, with varying degrees of occlusive changes, perivascular lymphocytes cuff-like infiltration, neutrophil infiltration and nuclear fragmentation, but Lymphocytes and histiocytes were the main components. The elastic tissue staining showed that the elastic fibers of the inner and outer elastic membranes were severely broken. The luminal occlusion and the corresponding lobular areas showed different degrees of panniculitis. Immunopathological examination revealed T lymphocytes in the lesions. Infiltration is dominant.
Diagnosis
Diagnosis and diagnosis of nodular vasculitis
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.
