nodular brittle disease
Introduction
Introduction to nodular fragility Nodular fragility (trichorrhexisnodosa) can cause hair nodules or fractures due to defects in hair shaft development, such as perming, hair dyeing or improper grooming. Can occur at any age, more common in women. The clinical manifestations are 1 to 2 nodules on the hair shaft, and a few patients may have more nodules. The patient can not easily detect that if more hair is involved, the hair becomes brittle and easily broken. basic knowledge The proportion of illness: 0.0035% Susceptible people: no special people Mode of infection: non-infectious Complications: sarcoidosis
Cause
Nodular fragility
Genetic factors (35%)
The disease is associated with hereditary metabolic diseases, especially arginine succinate deficiency, patients with increased urinary arginine succinate are susceptible to the disease, congenital may be autosomal recessive.
Physical and chemical factors (35%)
Physical or chemical factors that cause damage to the hair shaft can cause the disease, such as multiple perm, hair dyeing, straightening, causing damage to the hair shaft and causing nodular swelling. The hair shaft can be broken here to leave a broomstick or brush. Stump.
Other factors (10%)
Factors such as systemic disease, infection or nutritional deficiencies may also be associated with this disease, which may cause hair nodules or fractures due to defects in hair shaft development.
Prevention
Nodular fragility prevention
1. Try not to overheat and straighten your hair too often. These hot-dyeing and straightening hair syrups contain chemical components, which are harmful to the human body. If used frequently, they will cause no small disadvantages.
2. Eat more sesame seeds, oranges, etc. in your life, and add more foods rich in vitamin C and amino acids. This can supplement your hair with nutrients and prevent hair fragility, thus preventing the effect of nodularity on the disease.
3, usually pay attention to the protection of body hair, use some hair conditioner for hair, etc., in addition to hair, body hair is also possible nodular on the onset, so also need more protection and attention. Beauty starts with protecting yourself.
Complication
Nodular fragility complications Complications
The disease is usually due to physical or chemical damage caused by nodular swelling, skin integrity is destroyed, it can be caused by skin scratching caused by bacterial infection or fungal infection, usually secondary to low body, or long-term use of immunosuppression Agents and patients with fungal infections such as onychomycosis, such as concurrent bacterial infections may have fever, skin swelling, ulceration and purulent secretion. Severe cases can lead to sepsis, which should be brought to the attention of clinicians.
Symptom
Nodular fragility symptoms common symptoms scaly nodules low molecular proteinuria
The disease can occur in any age of both sexes, but it is more common in women. One or several yellow-white or gray-white nodules are swollen on the hair shaft, and the arrangement is irregular. The mechanical damage caused by combing or scratching can make nodules. Longitudinal splitting or breakage occurs in the inflated area, and the hair is brushed at the broken part. The hair is not completely broken. The two hairbrushes are relatively embedded. If the number of fractures is large, it may resemble incomplete alopecia. The head can also occur in pubic hair, mane and chest hair. Microscopic examination reveals that the small skin is broken at the nodule, the fur is fissed into filaments, some are unbroken, and some are completely broken, just like two brushes are opposite each other. Interspersed, under the electron microscope, the hair is round or oblate, twisted, the hair is longitudinally split, the hair ends are bifurcated, the surface of the nodule is scaly, and sometimes the arginine amber is visible.
Examine
Nodular fragility check
Laboratory tests: urine routine, sometimes arginine amber urine.
Other auxiliary examinations: microscopic examination showed that the small skin was broken at the nodules, the fur was fissured into filaments, some were unbroken, and some were completely broken, just like the two brushes were inserted opposite each other. Under electron microscopy, the hair is round or oblate, twisted, and the hair shaft is longitudinally divided, and the surface of the hair ends is bifurcated.
Diagnosis
Diagnosis and diagnosis of nodular fragility
Combined with symptoms and examinations can be diagnosed, but should be differentiated from rosary hair, head lice and alopecia areata.
Monilethrix: is a congenital hair malnutrition, often systemic, dry and uneven thickness, many nodules, beaded, easy to break between nodules. The beaded hair is autosomal dominant. The disease mostly begins in infants, and some patients are seen after puberty.
Tinea capitis: refers to the dermatophyte infection of hair and scalp, which occurs in children and is rarely infected in adults. Pathogenic bacteria are found only in two genera, Trichophyton and Microsporum.
