reactive perforating collagen disease
Introduction
Introduction to reactive perforating collagen disease Reactive perforating collagen disease (reactive perforating collagenosis) is rare, the incidence is often related to trauma, family history is obvious, may be autosomal recessive inheritance. basic knowledge The proportion of illness: 0.002%-0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: fever
Cause
Causes of reactive perforating collagen disease
(1) Causes of the disease
The onset is often associated with trauma, with a family history that may be autosomal recessive.
(two) pathogenesis
The pathogenesis is still not clear.
Prevention
Reactive perforating collagen disease prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Reactive perforated collagen disease complications Complications
The onset is often related to trauma, and the family history is obvious. It may be autosomal recessive. Because the disease may be accompanied by itching and the skin integrity is destroyed, it may cause skin bacterial infection or fungal infection due to scratching, usually secondary to Patients with low constitution, long-term use of immunosuppressants and fungal infections such as onychomycosis, such as concurrent bacterial infections may have fever, skin swelling, ulceration and purulent secretion.
Symptom
Symptoms of reactive perforating collagen disease Common symptoms
Skin damage is the size of the cap needle keratotic papules, gradually increasing, diameter about 5 ~ 6mm, normal skin color, smooth surface, central umbilical fossa depression, embedded with brown horn plugs (not easy to peel off), rash arranged linear Cluster, about 4 to 6 weeks can naturally subside, residual temporary hypopigmentation, soon there may be a new rash next to it, occurs in children under 12 years old, more common in the trunk, limbs and face, slightly itchy.
Examine
Examination of reactive perforating collagen disease
Histopathology: early epidermis thinning, cupped depression, widened dermal papilla, basophilic degeneration of collagen fibers, parakeratosis visible under the late cup-shaped lesion, cell debris and denatured collagen fibers forming angle plugs, embedded in the cup through the cup bottom In the epidermis, the epidermis is necrotic and contains no elastic fibers. The number of capillaries in the upper part of the dermis increases, and a few lymphocytes and tissue cells infiltrate.
Diagnosis
Diagnosis and identification of reactive perforating collagen disease
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed. It should be differentiated from skin penetrating hair follicles and follicular keratosis (Kyrle disease), penetrating folliculitis and claudication penetrating fibrosis.
