fungal disease
Introduction
Introduction to worm The disease is characterized by nasal mucosal polyps and extensive palpable subcutaneous localized masses. The pathogen is Conidiobolus coronatus, which originates from the nasal septum and gradually reaches the subcutaneous tissue in the sinus, throat and facial area. Living in tropical rainforests in Africa, especially in Nigeria. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific people Mode of infection: non-infectious complication:
Cause
Insect pathogen
(1) Causes of the disease
The pathogen is Conidiobolus coronatus, which is a subcutaneous tissue that begins in the nasal septum and gradually reaches the sinus, throat, and central area of the face. It is characterized by nasal mucosal polyps and extensive palpable subcutaneous localized masses.
(two) pathogenesis
The anterior turbinate is swollen at the initial onset, and the progression is slow. Even the disease may progress to the mucosa, the nostrils, the mouth and the sinus. The lesions are often bilateral, even unilateral. The enlargement of the mass may cause painless damage to adjacent tissues. Hyphae are more easily stained by HE, but PAS, Gridly is not easy to color, CMS dyeing is also weak, hyphae are single or clustered, the average diameter is 8m, the rule is regular, the wall is thin, but it is easy to confirm, surrounded by bright radial There are particles of eosinophilic substance, 2 ~ 6m thick, the eosinophilic substance is arranged in a finger or star shape, similar to the stellate of spores, the hyphae does not invade the blood vessel wall.
Prevention
Insect prevention
The fungal disease is mainly in the tropical rain forest climate. Corynebacterium infection in the nasal mucosa, sinuses, throat and subcutaneous tissue in the central area of the face leads to symptoms such as swelling of the turbinate, mucosal edema and painless damage of adjacent tissues. Therefore, the focus of prevention is to avoid going to tropical rain forests and avoid deepening into the tropical jungle. If necessary, please take protective measures to avoid infection with Coronaria.
Complication
Insect complication Complication
It mainly causes local complications of the nasal cavity. The enlargement of the mass can cause painless destruction of adjacent tissues. At the same time, the mass can adhere to the underlying tissue structure, and the convex and concave are uneven, and the turbinate can be blocked in the direction of the septum to block the nostril channel. Accompanied edema can affect the cheeks, forehead, lips, eyelids can also be closed due to swelling, resulting in corneal leukoplakia, ventilation space disappeared, mucosa thickened, the patient's blood is normal, no fever.
Symptom
Symptoms of worm disease Common symptoms Turbinate swelling and edema
At the initial onset, the anterior turbinate is swollen and progresses slowly. Even the sinus can progress to the mucosa, nostrils, mouth and sinus. The lesions are often bilateral, even unilateral. The enlargement of the mass can cause painless damage to adjacent tissues. The mass can be Touch, not adhere to the skin above it, but can adhere to the underlying tissue structure, uneven, push the turbinate to the septum can block the nostril channel, accompanied by edema can spread to the cheeks, forehead, lips, eyelids can also be closed due to swelling Causes corneal leukoplakia of the eye, X-ray shows opacity of the sinus; ventilation space disappears, mucous membrane thickens, the patient's blood is normal, and no fever.
Examine
Insecticide inspection
1. Direct microscopic examination of a soft and complete capsule puncture fluid or infected nasal mucosa scrapings for KOH smear see wide hyphae, occasionally separated, mycelial wall sees birefringence, branching.
2. The fungus cultured sandcastle culture medium (without chlorhexidine) showed white smoothness at the beginning of the colony, and the gradient was light brown. Colony microscopic examination showed sporangia of conidia of mononuclear cell size.
Histopathology: hyphae in tissues are more easily stained by HE, but PAS, Gridly is not easy to color, CMS is also weak, hyphae are single or clustered, the average diameter is 8m, the rule is regular, the wall is thin, but it is easier to confirm. Surrounded by bright radial, granular eosin, 2 ~ 6m thick, this eosinophilic substance is arranged in a finger or star shape, similar to the stellate of spores, the hyphae does not invade the blood vessel wall.
Diagnosis
Diagnosis and identification of worm
According to clinical manifestations, according to laboratory tests, histopathological examination revealed a stellate resembling spores, which can be diagnosed.
