Persistent Lenticular Hyperkeratosis

Introduction

Introduction to persistent bean keratosis Peripheral hyperkeratosis (hyperkeratosislenticularisperstans) This disease is a hyperplasia of the shape of the back of the foot and limbs, such as convex mirror or lentils, which is clinically rare. May be an autosomal dominant genetic disease. basic knowledge The proportion of illness: the incidence rate is about 0.003% - 0.007% Susceptible people: no specific people Mode of infection: non-infectious Complications: erythema

Cause

Causes of persistent lenticular hyperkeratosis

(1) Causes of the disease

May be autosomal dominant.

(two) pathogenesis

The pathogenesis is still unclear.

Prevention

Persistent lenticular hyperkeratosis prevention

The disease belongs to chromosomal diseases, and the cause of chromosomal abnormalities is unclear. It may have certain correlation with environmental factors, genetic factors, dietary factors, and mood and nutrition during pregnancy, so this disease cannot be directly prevented. Early detection, early diagnosis, and early treatment are important for preventing this disease. Regular examination should be carried out during pregnancy. If the child has a tendency to develop abnormalities, chromosome screening should be done in time. After the definition, the abortion should be considered according to the condition of the child to avoid the birth of the child.

Complication

Persistent lenticular hyperkeratosis Complications

Because the disease is a chromosomal-related disease, the disease is generally not associated with other lesions alone, and the number of cases is too small, and the complications are not clear. However, due to the existence of genetic high risk factors, there may be other related genetic diseases, including poor skin keratosis, congenital malformations of organ organs, hydrocephalus, etc., but the risk of obtaining this disease is extremely low, generally only As an exclusionary diagnosis.

Symptom

Persistent lenticular hyperkeratosis symptoms Common symptoms Itching erythema scaly rash

Occurs in men aged 30 to 60 years old, the damage is first on the back of the foot, the needle is a large reddish flank keratotic papule, the surface is rough, or erythema scaly, shaped like a convex mirror or lentil-like isolated rash, central The scales are thicker and the peripheral scales are fine. If the scales are peeled off, small bleeding spots can be seen, which are psoriatic lesions. Most of the early lesions are limited. Later lesions increase, involving the calves, arms, palms, etc. The lesions of the ankle are needle-like keratotic papules and dimples, the lesions are symmetrically distributed, the trunk is rare, the course of disease is prolonged, and the life span is sustainable, and the symptoms are absent or mild.

Examine

Examination of persistent lenticular hyperkeratosis

Histopathology: hyperkeratosis of the epidermis, occasional focal keratosis, thinning of the spinous layer, the typical change is that the thickened stratum corneum is papillary, similar to the apex, in sharp contrast with the flat spine. A narrow band-like infiltrate is visible in the upper layer of the dermis, mainly lymphocytes and histiocytes.

Diagnosis

Diagnosis and identification of persistent bean keratosis

diagnosis

According to the sacral keratotic papules mainly composed of limbs, the histopathological features of the characteristic apex-like hyperkeratosis can be diagnosed.

Differential diagnosis

1. Stucco keratosis keratinized papules are easy to remove, and there is no bleeding point under them.

2. Hair follicles and hair follicle parakeratosis (Kyrle disease) There is a horny plug in the center of the skin lesion, removing the horny plug, showing a crater-shaped depression, which may involve any part, but the palmar sac is rare, and the pathological change is excessive keratosis of the follicle. The keratinization is incomplete and there is a phenomenon of penetration into the dermis.

3. The pathological changes of psoriasis are characteristic and can be identified.

4. Others such as sacral keratosis, seborrheic keratosis, flat warts, the first two have no dermal damage, and the latter epithelial cells have vacuolar degeneration.

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