keratosis erythematosus
Introduction
Introduction to variability erythematous keratosis Variant erythrocytic keratosis (variable erythrokeratoderma), also known as variability erythrocytic keratosis dermatitis (erythrokeratodermia figuratavariabilis) or Mendesdacosta erythrocytic keratosis (Mendesdacosta type erythrokeratodermia), is autosomal dominant, the pathogenesis is -4gapjunction The protein (connexin31) is a mutation, and its variant gene is located in the chromosome 1p34-p35 region. Most of the disease occurs in the short-term after birth, and it improves with age. It can be regressed after menopause, but the condition worsens during pregnancy, cold, heat, and wind stimulation. Emotional excitement can be aggravating the cause. Skin lesions are more common in the extremities, arms and face of the extremities, and some patients have keratinization of the palmar palpebral. basic knowledge The proportion of sickness: 0.01% Susceptible people: good for teens Mode of infection: non-infectious Complications: erythema
Cause
Etiology of variegated keratosis
(1) Causes of the disease
The disease is autosomal dominant, which is caused by mutation of -4 gap junction protein (connexin 31), and its variant gene is located in chromosome 1p34-p35 region.
(two) pathogenesis
It is autosomal dominant, which is caused by mutation of -4 gap junction protein (connexin 31), and its variant gene is located in chromosome 1p34-p35 region.
Prevention
Variability erythema keratosis prevention
Marriage and childbirth guidance, premarital examination, and genetic counseling are the key to preventing this disease.
Complication
Variability of variegated keratosis Complications
No special complications.
Symptom
Symptoms of variegated keratosis common symptoms, hyperkeratosis, epidermal hyperkeratosis, diffuse vascular keratosis
Most of them occur soon after birth, a few births or youth, the disease improves with age, can be resolved after menopause, but the condition worsens during pregnancy, cold, heat, wind stimulation and emotional excitement can aggravate the cause and damage There are two kinds, one is a relatively fixed deep red keratinized plaque, the boundary is like a knife cut, rounded, comma-shaped, multi-ring or ring; the other is the obvious erythema, the size The number and location are different. In a short time (hours or days), the size of the form can change or completely subside. It can also develop into a fixed shape. The lesions are more common in the extremities, arms and face, and some patients. With palmar keratinization.
Examine
Examination of variegated keratosis
Histopathology: Non-specific changes, visible hyperkeratosis, parakeratosis, thickening of the spinous layer, moderate papillary hyperplasia, mild edema of the dermis and non-specific inflammatory cell infiltration.
Diagnosis
Diagnosis and identification of variegated keratosis
According to the characteristics of early onset and damage, histopathology can be diagnosed.
1. Hair red pity skin lesions are characteristic brown red or reddish hair follicle keratotic papules, which have a wide distribution range, dry scaly skin lesions on the head and face, excessive keratosis of the palmar, dry and chapped, slow The range is wide, especially in the first and second sections of the back of the finger, which is particularly noticeable.
2. Verrucous keratosis is more common in prepuberty, and the damage is mostly clustered flat sputum papules, distributed in groups, hard and distributed on the dorsal side of the hands and feet, sometimes arranged in a line along the fingertips.
