prevasculitic syndrome
Introduction
Introduction to pre-vasculitis syndrome Pre-vasculitis syndrome is an autoimmune systemic vascular disease similar to Still's disease. Its clinical manifestations resemble Still's disease, but the laboratory tests are different. basic knowledge The proportion of illness: 0.003% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
Causes of pre-angiogenic syndrome
(1) Causes of the disease
At present, it is generally believed that it is related to immune response or other pathogenic factors. Bacterial or viral infections in the respiratory tract or other parts may be the cause of the disease. Because the disease mainly involves the vascular system (arterial), it is speculated that there may be allergies to the drug. A certain relationship.
(two) pathogenesis
It is impossible to deny the role of specific physique in the responsiveness of sensitizing substances in the pathogenesis of this disease. Lymph node biopsy shows increased reactive reticular cells; skin biopsy shows inflammatory cell infiltration or granuloma formation, no fibrin-like necrosis Histological changes in vasculitis.
Prevention
Prevention of anterior vasculitis
Early diagnosis, early treatment, the disease in the absence of heat, if a small dose of hormones, immunosuppressive drugs to adequately maintain treatment, until the gamma globulin drops to normal and then stop the drug, can prevent its recurrence.
Complication
Vascular proinflammatory syndrome Complication
Currently there are no related content description.
Symptom
Symptoms of pre-vasculitis syndrome Common symptoms Leukopenia Relaxation heat joint pain Hyperthermia
Most patients have symptoms of subacute or chronic upper respiratory tract infection. The disease is characterized by relaxation and thermal sepsis. After several weeks or months, intermittent fever can occur gradually. At the same time, urticaria-like, measles-like rash or localized erythema occurs. The erythema occurs in the face, limbs, palms, ankles, etc. Most patients may have mild joint pain in the presence of skin lesions. Even in high fever, peripheral blood leukocytes may have different degrees of decline, another disease of the disease It is characterized by the absence of abnormal findings of kidney damage such as proteinuria throughout the course of the disease.
Examine
Examination of anterior vasculitis syndrome
1. Blood routine and blood sedimentation peripheral blood leukocytes increased early, and then decreased slightly, and erythrocyte sedimentation rate increased significantly.
2. Immunological examination of rheumatoid factor positive, Coomb test can also be positive, but anti-nuclear antibodies, anti-DNA antibodies and LE cells are mostly negative, serum complement slightly increased, serum gamma globulin increased.
Diagnosis
Diagnosis and differentiation of anterior vasculitis syndrome
According to fever, accompanied by skin lesions, leukopenia and histological changes, diagnosis is not difficult.
The disease is easily confused with systemic lupus erythematosus in the clinic, but the serum immunological findings of this disease are often the opposite of systemic lupus erythematosus. S. aureus sepsis sometimes shows a high fever for a long time, accompanied by urticaria-like The rash is similar to this disease, but the former has no immunological abnormalities and is effective for antibiotic treatment. The latter has immunological changes, is ineffective for antibiotic treatment, is effective for hormone therapy, and has urticaria or measles-like rash when nodular polyarteritis occurs. At the time, its clinical manifestations are very similar to this disease, but the former has multiple systemic features, and its histopathological changes are fibrin-like necrotic vasculitis, which are easier to identify.
The disease needs to be differentiated from Still's disease and immune hyperplasia syndrome. The skin rash of Still's disease is often transient. The white blood cells are obviously increased when the disease is active, and the joint disease is obvious. These are different from the disease, and the immune dysplasia syndrome can be For relaxation heat, systemic lymphadenopathy, biopsy in addition to reticular cell hyperplasia, accompanied by lymphatic network changes, easy to identify the disease.
