Hepatic epithelioid hemangioendothelioma
Introduction
Introduction to hepatic epithelioid vascular endothelial cell tumor Hepatic epithelioid vascular endothelial cell tumor is a rare hepatic vascular tumor. Weiss and Ensinger first described superficial or deep soft tissue endothelial cell tumors. A lung-like tumor was originally called vascular endothelial cell bronchoalveolar tumor. It was first thought to be a metastatic tumor in the liver, and it was later discovered by Ishak as a primary tumor of the liver. Tumor growth is slow, the prognosis is different, biologically critical tumor, between benign hemangioma and malignant angiosarcoma, no toxic substance contact and history of hepatitis virus infection. Without cirrhosis, there is more metastasis at the time of initial diagnosis. basic knowledge The proportion of sickness: 0.003%-0.007% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
Causes of hepatic epithelioid vascular endothelial cell tumor
(1) Causes of the disease
The cause of this disease is still unclear.
(two) pathogenesis
Multiple lesions in the liver, the diameter of the lesions range from a few millimeters to several centimeters, the tumor tissue is tough, the brownish yellow is white, the cut surface is a gravel-like structure, and there is no cirrhosis.
Histological examination of the tumor nodule boundary is unclear, often involving multiple adjacent liver acinar, such as the end of the liver venules and portal area, but these structures remain clear, tumor cells often along the sinusoids, terminal venules and portal vein branches Proliferation, or invasion of the Glisson sheath, the proliferation of tumor cells in the acinar causes the liver plate to gradually shrink and eventually disappear; the tumor can also form emboli, polyps or clusters in the vein, and the tumor cells are irregular in shape, with multiple Canine staggered, "dendritic" cells, or round, containing cytoplasmic "epithelial cell-like" cells, which can be seen in nuclear heterogeneous and schizophrenic, tumor cells with many epithelial characteristics, both Basement membrane, vesicle vesicles and Weibel-Palade bodies, which differ from normal epithelial cells in that tumor cells contain a large number of cytoplasmic microfilaments, and there are a large number of dense bodies in tumor cells.
Prevention
Hepatic epithelioid vascular endothelial cell tumor prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Hepatic epithelioid vascular endothelial cell tumor complications Complication
There is no complication of this disease.
Symptom
Hepatic epithelioid vascular endothelial cell tumor symptoms Common symptoms Loss of appetite Liver splenomegaly Abdominal pain Astragalus systemic failure Steady anorexia
Gastropin loss, anorexia, nausea, paroxysmal vomiting, upper abdominal pain, weight loss, signs of hepatosplenomegaly, 20% of patients may have jaundice, advanced patients with systemic failure, occasionally patients with symptoms similar to Budd-chiari syndrome .
Examine
Examination of hepatic epithelioid vascular endothelial cell tumor
No specificity, including ALP, GGT increased, AFP, CEA normal.
Abdominal plain film shows liver calcified area, similar to colon cancer liver metastasis, B-ultrasound is a plurality of nodules with uneven echo; CT manifestations are also diverse, showing multiple low-density areas with peripheral vascular shadows moderately enhanced, more tumors A low blood vessel point, sometimes a small bile duct dilatation, some intrahepatic portal vein branches are not developed, the liver contour is unchanged; angiography shows multiple low blood vessel masses in the liver.
Diagnosis
Diagnosis and identification of hepatic epithelioid vascular endothelial cell tumor
At present, only relying on liver pathology can confirm the diagnosis.
