Pediatric Asthmatic Muscular Dystrophy Syndrome
Introduction
Introduction to asthmatic muscular atrophy syndrome in children Asthmatic amyotrophic syndrome (asthmatic amyotrophy), Hopkins syndrome (Hopkinssyndrome), also known as acute asthma with polio-like damage, the main feature of this disease is about 1 week after the onset of asthma in children, similar Spinal anterior polio-like flaccid paralysis of the single limb. basic knowledge Sickness ratio: 0.001%-0.002% Susceptible people: children Mode of infection: non-infectious Complications: muscle atrophy
Cause
The cause of asthmatic muscular atrophy syndrome in children
Infection (30%):
According to the increase in the number of cells in the cerebrospinal fluid of children, the nature of the lesion belongs to inflammation. It is speculated that it may be caused by a neurotropic undetermined virus infection. Due to the application of infection and hormones, the immune function of children with asthma is further inhibited, so that the potential virus in the body can invade the spinal cord. The anterior horn causes disease.
Spinal anterior polio (15%):
It may be caused by inflammation of the anterior horn of the spinal cord or anterior root caused by low immunity after the onset of asthma after immunization with live polio vaccine, but some children who have been immunized with intact polio vaccine before the onset of the disease Separation of feces and cerebrospinal fluid virus failed to isolate the poliovirus, and the serum poliovirus antibody titer did not increase, but denied the poliovirus infection.
Drug induced (20%):
It is related to the application of aminophylline, but not all cases have been treated with xanthine derivatives, and no other neurotoxic drugs have been applied, so it is difficult to establish.Prevention
Prevention of asthmatic muscular atrophy syndrome in children
There are no reliable preventive measures, but active prevention and treatment of various infectious diseases.
1, exercise
It can promote blood circulation and metabolism, improve respiratory function, enhance muscle tension, and improve the body's ability to adapt to changes in temperature and external environment. At the same time, it promotes appetite, maintains a happy spirit, and improves the body's ability to resist disease.
2. Reduce the mental stimulation and ideological burden of sick children
Asthma is also a psychosomatic disease. Because the onset of asthma is related to nervous system excitability, encourage them to participate in group activities, learn to manage themselves, and reduce the onset of asthma.
Complication
Complications of asthmatic muscular atrophy syndrome in children Complications muscle atrophy
After a long time, the affected limbs showed paralysis and muscle atrophy, and most of them were difficult to recover.
Symptom
Symptoms of Asthma Muscular Atrophy Syndrome in Children Common Symptoms Reflexes Disappear Muscle Tension Reduces Muscle Injury Muscles Disuse Atrophy Limbs Insufficient Meningeal Stimuli
More common in boys aged 2 to 11 years, in the infancy or before the onset of a complete polio live vaccine immunization, used hormones, theophylline drugs, etc., 4 to 11 days after the onset of asthma Rapid unilateral limb flaccid paralysis can occur, limb weakness can occur, muscle tension in the affected limbs is reduced, tendon reflexes disappear, but no paresthesia is abnormal. Half of the cases may have meningeal irritation and mild muscle pain and tenderness.
Examine
Examination of asthmatic muscular atrophy syndrome in children
1. Cerebrospinal fluid examination:
In all cases, the number of cells increased, mainly lymphoid or neutrophils.
2. Separate the virus:
Poliovirus was not isolated from cerebrospinal fluid and feces, and other viruses were isolated from feces in a few cases, such as ECHO18, Coxsackie B6, and adenovirus type III.
3. Virus antibodies:
Serum poliovirus antibody titers did not increase.
4. Electromyogram examination:
The electromyogram is a neuronal change, and the motor nerve conduction velocity is slowed down.
5. Brain CT examination:
Choose according to clinical needs.
Diagnosis
Diagnosis and diagnosis of asthmatic muscular atrophy syndrome in children
diagnosis
Diagnosis based on medical history, planned immunization history, clinical manifestations and related tests.
Differential diagnosis
Must be further identified with polio.
