Eosinophilic relapsing granulomatous dermatitis
Introduction
Introduction to eosinophilic recurrent granulomatous dermatitis Recurrentgrannulomatousdermatitiswitheosinophilia, also known as Eosinophilic cellulitis, is also known as Wells syndrome in 1971 by Wells. basic knowledge The proportion of illness: 0.03% Susceptible people: no special people Mode of infection: non-infectious complication:
Cause
Etiology of eosinophilic recurrent granulomatous dermatitis
(1) Causes of the disease
May be an allergic reaction, most patients are completely unknown, and some are related to arthropod bites, drug allergies, parasitic infections, congenital allergies, visceral malignancies, and skin fungal infections.
(two) pathogenesis
The pathogenesis is still unclear.
Prevention
Eosinophilic recurrent granulomatous dermatitis prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Eosinophilic recurrent granulomatous dermatitis complications Complication
Currently there are no related content description.
Symptom
Eosinophilic recurrent granulomatous dermatitis symptoms Common symptoms Granuloma edema skin itching
Repeated large edematous erythema, similar to acute cellulitis, formed painless, invasive granulomatous intradermal and subcutaneous tissue masses after a few days, typical lesions are located in the upper back, limbs or buttocks, lesions progressing Hardening, can completely disappear within 2 months, systemic symptoms can have fever, asthma and joint pain, most patients with increased eosinophils in peripheral blood.
Examine
Examination of eosinophilic recurrent granulomatous dermatitis
Cytopathology: dense eosinophil-based infiltration in the early dermis, many eosinophils exhibit degranulation, infiltration can extend to subcutaneous tissue, and even underlying muscle, granulomatous lesions, Eosinophils can be seen in extensive degranulation, with bright red particles on the collagen fibers, forming a characteristic "flame figure", some of which are surrounded by eosinophils, macrophages and giants. The cells are surrounded by a fence, and the center can form a gradual necrosis.
Diagnosis
Diagnosis and differentiation of eosinophilic recurrent granulomatous dermatitis
The disease should be differentiated from persistent inflammatory erythema. There is no infiltration layer under the epidermis, and the eosinophils in the infiltration are significantly increased, while there is almost no eosinophil in the persistent inflammatory erythema infiltration, and there is no infiltration zone. At the same time, it should be differentiated from the skin tuberculosis of the face. The clinical manifestations of the two are similar, but the pathological examination shows the pathological changes of tuberculous granuloma.
