Intraepidermal neutrophil IgA skin disease
Introduction
Introduction to neutrophil IgA dermatosis in the epidermis Intraepidermal neutrophilic IgAdermatosis is a chronic bullous skin disease reported by Huff et al in 1985 in adult males with special histopathology and immunological manifestations. basic knowledge The proportion of sickness: 0.00125% Susceptible people: good for adult males Mode of infection: non-infectious Complications: polymorphic erythema
Cause
The cause of neutrophil IgA dermatosis in the epidermis
(1) Causes of the disease
The cause is still unclear.
(two) pathogenesis
Histopathology: Neutrophil extravasation at some true epidermal junctions of neutrophils arranged in a line, followed by the formation of micro-abscess in the epidermis, without spine release.
Direct immunofluorescence showed intercellular IgA deposition, and the basal cell layer also had mildly stained, non-circulating autoantibodies.
Prevention
Prevention of neutrophil IgA skin disease in the epidermis
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Symptoms of neutrophil IgA dermatosis in the epidermis Complications polymorphic erythema
No special complications.
Symptom
Symptoms of neutrophil IgA in the epidermis Common symptoms Pustular skin blisters or bullae damage scarring skin blisters, posterior...
It can be divided into two types, one is similar to pemphigus, the other is similar to pustulosis under the cornea. The former is a generalized loose blisters, which quickly breaks down, scars, no scars after the healing, no mucosal damage. Does not affect the limbs, face and neck, the skin lesions are irregularly arranged, the latter is a limp and ring pustule.
According to its characteristic clinical manifestations, histopathological changes and immunopathological intercellular IgA deposition can be basically determined.
Examine
Examination of neutrophil IgA skin disease in the epidermis
Histopathology: neutrophil extravasation, at some true epidermal junctions, neutrophils are arranged in a line, followed by the formation of micro-abscess in the epidermis, without spine release.
Direct immunofluorescence showed intercellular IgA deposition, and the basal cell layer was also slightly stained with no circulating autoantibodies.
Diagnosis
Diagnosis and differentiation of neutrophil IgA skin disease in the epidermis
According to its characteristic clinical manifestations, histopathological changes and immunopathological intercellular IgA deposition can be basically determined.
