obesity pain
Introduction
Introduction to painful obesity Painful obesity (adiposisdolorosa) is a rare autonomic nervous system disease of unknown etiology. It is characterized by abnormal accumulation of subcutaneous fat in some parts of the body, accompanied by spontaneous pain in this part. People with painful obesity have a family history. Often children with painful obesity also have painful obesity. Obesity caused by genetic factors is often obese from childhood, accompanied by hyperlipidemia or hyperlipoproteinemia. basic knowledge The proportion of illness: 0.003%-0.004% Susceptible people: no specific population Mode of infection: non-infectious Complications: depression, dementia
Cause
Causes of painful obesity
(1) Causes of the disease
The disease may be related to metabolic disorders, and there are reports that it is related to immune dysfunction, but it has not yet been elucidated.
(two) pathogenesis
The pathogenesis is unknown. In the past, it was thought to be related to hypothalamic and endocrine disorders. However, Pimenta et al. (1992) confirmed that the pituitary, adrenal gland, thyroid gland and gonads have normal secretion function, and patients are found to have peripheral insulin resistance. Normal intake and oxidation, low response to norepinephrine, lack of insulin anti-fat solubilization, it is believed that this disease may be related to metabolic disorders, may cause local pain due to abnormal fat accumulation affecting the cutaneous nerve, but also due to cutaneous neurodegeneration It leads to a decrease in pain, and another literature suggests that it is related to immune dysfunction, but it has not yet been elucidated.
Prevention
Painful obesity prevention
The law of life: Maintain good living habits, arrange your own sleep time according to different ages, not only to meet physiological needs, but also to sleep too much.
Keep your mood comfortable: Good mood can keep the physiological functions of various systems in the body running normally, and it can play a role in preventing obesity.
Complication
Painful obesity complications Complications Dementia Dementia
Depression, mental decline, mental decline, or progression to dementia can occur.
Symptom
Symptoms of painful obesity Common symptoms Obesity and painful nodules... Adolescent obesity depression, depression, menopause, severe pain, postpartum obesity, drug obesity
1. The majority of female patients with this disease, the age of onset is 30 to 50 years old, that is, women of childbearing age, often accompanied by early menstruation, early decline in sexual function and other symptoms, mainly manifested as painful nodules on the basis of obesity or Fat blocks, varying in size, fat deposits on the trunk, neck, ankle and waist and hips. The distribution is asymmetrical, the early fat nodules are soft, and the late stage is hard. As the fat nodules increase, the pain increases. At the same time, there are numbness, weakness and sweating disorders.
2. The nature of the pain is acupuncture or knife-like pain, which is paroxysmal or persistent. There may be tenderness along the nerve trunk, often accompanied by joint pain. Systemic weakness is a prominent symptom, but there is no evidence of organic disease. .
3. The disease is chronically progressive, often with psychiatric symptoms such as depression and mental retardation, as well as mental decline, and a tendency to develop into dementia.
Examine
Examination of painful obesity
1. Blood, urine routine examination and cerebrospinal fluid routine examination are mostly non-specific.
2. Blood sugar, islet antibody test has auxiliary and differential diagnosis significance.
3. The skull, the majority of limb imaging examinations are normal results.
4. Autonomic nerve function tests may have sweating disorders and the like.
Diagnosis
Diagnosis and identification of painful obesity
A characteristic painful fat nodule appears on the basis of obesity and can be diagnosed according to the age and gender of onset.
1. Nodular febrile nonsuppurative panniculitis is a chronic disease, recurrent, scattered subcutaneous nodules, but no spontaneous pain, normal or red skin color, brown or purple Most patients have fever, and often accompanied by skin lesions at the same time. The pathological manifestations are mainly the inflammatory reaction of subcutaneous fat and steatosis and necrosis.
2. Many patients with multiple neurofibromatosis often have many milk-coffee spots on their skin. Histopathological biopsy confirmed neurofibromatosis.
3. Multiple angiolipomas are characterized by tenderness and few spontaneous pains. The diagnosis can be confirmed by histopathological biopsy of lipoma.
