Malignant rhabdoid tumor of the vulva
Introduction
Introduction to vulvar malignant rhabdoid tumor Valignant rhabdomyosarcoma (malignantrhab-doidtumourofthevulva) was first reported in 1978 as a "prognosis of rhabdomyosarcoma-like Wilm's tumor". Although it resembles striated myoblasts, no evidence of striated muscle differentiation was observed by electron microscopy and immunohistochemistry. basic knowledge The proportion of sickness: 0.0052% Susceptible people: no special people Mode of infection: non-infectious Complications: retroperitoneal lymphadenitis
Cause
The etiology of vulvar rhabdomyosarcoma
Cause:
The malignant rhabdomyosarcoma of the vulva has different viewpoints such as striated muscle, neuroectoderm, histiocytosis, epithelial cells, melanocytes and mesenchymal cells, but no consensus has been obtained. It is still being further explored.
Pathogenesis
The tumor is a round or irregular mass with a rough surface, no envelope, and the cut surface is taupe or tan, which can be seen in the hemorrhagic foci.
Light microscopy showed high-grade malignant sarcoma images. The tumor cells were diffuse or irregularly nested. The characteristic features were most horn cells with rich eosinophilic cytoplasm, vesicular nucleus and obvious nucleoli. Partial nuclear deviation, most of the cytoplasm see transparent, blister-like eosin spherical inclusions, PAS-positive, under electron microscopy, the inclusion bodies consist of intermediate filaments or microwires arranged in a spiral or concentric shape.
Tumor cell cytoplasm and inclusion body vimentin, cytokeratin diffuse positive, Cytokeratin type, mainly CK8 and CK18 positive, most of the cell cytoplasm CD99, NSE, Leu7 and other positive.
Prevention
Prevention of vulvar malignant rhabdoid tumor
1. Maintain an optimistic and happy mood. Long-term mental stress, anxiety, irritability, pessimism and other emotions will make the balance of the cerebral cortex excitatory and inhibition process imbalance, so you need to maintain a happy mood.
2, life restraint pay attention to rest, work and rest, life orderly, maintain an optimistic, positive, upward attitude towards life has a great help to prevent disease. Do the regularity of tea and rice, live daily, not overworked, open-minded, and develop good habits.
3, reasonable diet can eat more high-fiber and fresh vegetables and fruits, balanced nutrition, including protein, sugar, fat, vitamins, trace elements and dietary fiber and other essential nutrients, meat and vegetables, diversified food varieties, Giving full play to the complementary role of nutrients in food is also helpful in preventing this disease.
Complication
Vulvar malignant rhabdoid tumor complications Complications, retroperitoneal lymphadenitis
Vulvar malignant rhabdomyosarcoma was first reported in 1978 as a "prognosis of rhabdomyosarcoma-like Wilm's tumor". Although it resembled rhabdomyoblasts in morphology, no evidence of striated muscle differentiation was observed by electron microscopy and immunohistochemistry.
The most common complication of vulvar malignant rhabdoid tumors is metastasis. The most common site of metastases is lung, followed by posterior peritoneal lymph nodes and liver.
Symptom
Vulvar malignant rhabdoid tumor symptoms Common symptoms Peripheral inflammation reaction subcutaneous nodular itching
Vulvar malignant rhabdoid tumors are mostly painless, active subcutaneous nodules, recently increased, size 2 ~ 6cm, can be accompanied by tenderness, the course of disease ranging from a few months to a year, most of which are located in the labia majora, haze Fewer.
Examine
Examination of vulvar malignant rhabdoid tumors
Tumor marker examination, immunohistochemistry, histopathological examination.
The routine examination of the genital gynecology is a preliminary routine examination of the vulva, which is used to provide a basis for further diagnosis, and at the same time prevent and timely treat vaginal diseases. Normal vulva, pubic hair is tip-down, triangular distribution, pigmentation of the labia majora, red labia minora, no ulceration of the perineum, dermatitis, sputum and hypopigmentation, clitoris length <2.5cm, pale pink around the urethral orifice, flawless biological.
Diagnosis
Diagnosis and diagnosis of vulvar malignant rhabdoid tumor
The diagnostic criteria for vulvar malignant rhabdoid tumors are: conventional HE light microscopy is possible, both electron microscopy and immunohistochemistry are affirmed, and the three are indispensable.
Because most of the anabolic eosinophils and cytoplasmic eosinophils can also be found in epithelioid sarcoma, synovial sarcoma, chondrosarcoma, malignant mesothelioma, rhabdomyosarcoma, leiomyosarcoma, Wilm tumor, etc., attention must be paid to identification, especially In recent years, "proximal" epithelioid sarcoma, Brand et al (2001) believe that it is not yet possible to completely distinguish the two, Saito et al (2001) found that epithelioid sarcoma including "proximal" mostly CD34 and -catenin Positive expression, and no expression in both malignant rhabdoid tumors, it is believed that immunohistochemical detection of CD34 and -catenin will help identify.
