vaccinia-like vesicular disease
Introduction
Introduction to vaccinia-like vesicular disease Vaccinia-like vesicular disease is an idiopathic photosensitive skin disease that has developed from childhood and is mainly vesicular, leaving scars behind. Summer blisters are the abnormalities of the disease, the symptoms are mild, and there is no scar after the healing. basic knowledge The proportion of illness: 0.002% Susceptible people: the incidence has started since childhood, usually 2 to 3 years old, more common in boys Mode of infection: non-infectious Complications: conjunctivitis keratitis hair loss
Cause
Causes of vaccinia-like vesicular disease
(1) Causes of the disease
The cause is unknown, Pick and Epstein have studied the disease successively, affirming that the disease occurs in men, and it is clear that there are strong genetic factors in some families.
(two) pathogenesis
The incidence is related to sun exposure, and its spectrum of action is mainly UVB. It has been reported in China that direct immunofluorescence is performed on 3 patients with this disease, and IgM deposition is found in the basement membrane band and dermal wall. It is speculated that it may be a metamorphosis caused by light. Reactive disease.
Prevention
Vaccinia-like vesicular disease prevention
Due to the reform of the modern milk milking process, it is usually completely replaced by mechanization. Therefore, the number of cases in which the disease is currently occurring is reduced. This disease often occurs in workers who are milking or slaughtering. It can also be caused by a false vaccinia virus infection. Therefore, vaccination against vaccinia should be carried out to reduce the chance of infection. For cows suspected of being contaminated with vaccinia virus, gloves should be worn when milking to reduce the chance of infection.
Complication
Vaccinia-like vesicular complications Complications Conjunctivitis keratitis alopecia
Can be accompanied by angulation, conjunctivitis and affect vision, but also nail deformity, hair loss.
Symptom
Symptoms of vaccinia-like vesicular symptoms Common symptoms Blisters or bullae damage redness herpes herpes erythematous papules hair loss alopecia herpes zoster-like appearance
The incidence has been from the beginning of childhood, usually 2 to 3 years old, more common in boys, the symptoms are alleviated during the growth period, and more can be relieved or stopped during puberty.
Skin lesions mainly occur in the exposed parts such as the face and back of the hand, especially in areas that are easily exposed to sunlight, such as the condyle, the bridge of the nose, the forehead, the upper edge of the ear shell, the lower lip and the back of the back of the hand. Red spots, pimples, quickly develop into blisters, as small as needles, as large as soybeans, often in groups, can also be distributed, some blister can have umbilical depression in the center, surrounded by mild inflammatory redness, similar to vaccinia, 3 to 4 days later Dry or ruptured and crusted, severe cases may have necrosis, black sputum, sag scars after detachment, or even deformed deformed, generally summer symptoms are aggravated, winter mitigation, sun exposure can induce or aggravate, mostly after sun exposure 1 to 2 days, issued in batches, each episode 2 to 3 weeks, before the appearance of skin lesions often have a burning or burning sensation, sometimes with itching, can be accompanied by horns, conjunctivitis and affect vision, there are also Nail deformity, hair loss, systemic symptoms are even lighter.
Examine
Examination of vaccinia-like vesicular disease
Histopathology: blister formation in the epidermis, blister fluid containing polymorphonuclear leukocytes, lymphocytes, cell debris and fibrin, with epidermal cell reticular degeneration and necrosis of the epidermis and adjacent dermis.
Diagnosis
Diagnosis and identification of vaccinia-like vesicular disease
The following diseases should be excluded from diagnosis: pleomorphic sun rash, discoid lupus erythematosus, erythropoietic protoporphyria and erythropoietic porphyria, often have to ask the history and conduct porphyrin and other related measurements, the disease is good There are scars in children and after the healing, unlike the vesicular herpes type.
It is also necessary to distinguish with summer pruritus and hereditary dermatitis with summer pruritus. Summer pruritus can occur in prepubertal children or adults. It is more common in women. The rash is more widespread and can be found in the face, neck, limbs and buttocks. The papules and small nodules can be lichen-like changes over a long period of time. There is no scar after the healing, and it often lasts for many years.
