intravascular large B-cell lymphoma
Introduction
Introduction to intravascular large B-cell lymphoma Intravascular large Bcell lymphoma is characterized by a large number of tumor B cells accumulating in the blood vessels, which invade the central nervous system and skin. basic knowledge The proportion of illness: 0.05-0.08% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
Causes of intravascular large B-cell lymphoma
(1) Causes of the disease
The cause is not clear.
(two) pathogenesis
The pathogenesis is still unclear.
Prevention
Intravascular large B cell lymphoma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Intravascular large B-cell lymphoma complications Complication
It is not clear about the complications.
Symptom
Intravascular large B-cell lymphoma symptoms common symptoms papular nodule reticular plaque dementia
The lesions are various in shape, some resembling classic lymphoma with purple papules or nodules. In others, they resemble endovascular embolism with reticular plaque-like lesions, sclerosing plaques can also occur, and central nervous system symptoms are obvious. With progressive dementia or multiple cerebral ischemia, the prognosis of this disease is very poor many months before the discovery of lymphoma.
Examine
Examination of intravascular large B-cell lymphoma
Histopathology: Histopathology has diagnostic value. It can be seen that the dermal and subcutaneous tissues are dilated and filled with large tumor cells. It can be seen that the extravascular tumor cells are focally clustered.
Immunohistochemistry: Tumor cells express CD19, CD20, CD22, CD79a and monomorphic surface immunoglobulins, and immunoglobulin gene clone rearrangements can be found.
Diagnosis
Diagnosis and identification of intravascular large B cell lymphoma
According to the clinical manifestations, the characteristics of skin lesions, histopathological features, immunohistochemical examination, can be diagnosed.
