hepato-thyroid syndrome
Introduction
Introduction to liver-thyroid syndrome HepatoThyroid Syndrome refers to a syndrome that has both chronic hepatitis and chronic thyroiditis and is associated with both causes. In 1960, MCConkey et al first reported that the intrinsic does not include liver damage caused by dysfunction of the liver caused by thyroid disease and liver damage caused by increased irritation of various causes; nor does it include systemic malnutrition caused by chronic liver disease. The function of the thyroid gland. basic knowledge The proportion of illness: 0.0021% Susceptible people: more common in women over 40 years old Mode of transmission: mother-to-child transmission Complications: arthritis edema ulcerative colitis pleurisy
Cause
Cause of liver-thyroid syndrome
The etiology of the intrinsic is still unclear. In recent years, there have been many reports of multiple endocrine gland immune diseases, such as Schimidt syndrome, ie, thyroid and adrenal gland simultaneous immunological diseases. Therefore, it is speculated that this syndrome may also be due to immune function. To the destruction, at the same time, autoantibodies (anti-thyroid antibodies and anti-liver antibodies) are produced to cause an immune response to their own tissues, causing simultaneous autoimmune diseases in both organs, liver diseases with varying degrees of fibrosis and lymphocytic infiltration; thyroid Diffuse or focal thyroid inflammatory changes.
Prevention
Hepatic-thyroid syndrome prevention
The disease should actively prevent the occurrence of liver disease and thyroid disease, and at the same time strengthen physical exercise and improve their own immunity.
Complication
Hepatic-thyroid syndrome complications Complications arthritis edema ulcerative colitis pleurisy
Patients with multiple arthritis, pleurisy, mild rash, edema, Raynaud phenomenon, ulcerative colitis.
Symptom
Hepatic-thyroid syndrome symptoms Common symptoms Liver palmar ascites Spider axillary lymph node enlargement Portal hypertension High-pressure transient lupus erythematosus
Women over the age of 40 have liver disease and goiter, and those with normal thyroid function can be diagnosed. Chronic hepatitis and portal cirrhosis should be excluded.
Intrinsic is more common in women over the age of 40, especially in menopausal women, thyroid and liver disease may be either first or later, can also occur simultaneously, diffuse thyroid enlargement, small nodules, more no tenderness; liver disease It shows liver enlargement, splenomegaly, spider mites, and even ascites. Late stage has similar portal hypertension. However, it is found that splenomegaly is not caused by portal hypertension, but is related to autoimmunity and antibodies. 50% of patients may have autoimmune manifestations such as fever, polyarthritis, pleurisy, mild rash, edema, Raynaud phenomenon and lymphadenopathy, sometimes with transient lupus erythematosus or scleroderma-like manifestations, or With ulcerative colitis and so on.
Examine
Hepatic-thyroid syndrome test
Laboratory tests for increased erythrocyte sedimentation rate, serum gamma globulin increased significantly (more than 25g / L or more), liver function showed BSP retention, bilirubin mildly elevated, transaminase increased, alkaline phosphatase increased slightly, cholesterol decreased The thyroid function is basically normal, urine protein is positive, PSP is reduced, mild renal function is impaired, white blood cells are reduced, and red blood cell life is slightly shortened.
Diagnosis
Diagnosis and differentiation of hepatic-thyroid syndrome
The disease should be differentiated from liver damage caused by intrahepatic circulatory disturbance or metabolic abnormality caused by thyroid disease and enhanced stimulation of various etiologies, and diseases caused by chronic liver disease causing systemic malnutrition and affecting thyroid function.
