Vaginal granulocytic sarcoma
Introduction
Introduction to vaginal granulocyte sarcoma Vaginal granulocyte sarcoma can be seen in relapsed acute myeloid leukemia, and can occur simultaneously with breast granulocyte sarcoma, as well as a report of acute myeloid leukemia by bone marrow biopsy due to vaginal granulocyte sarcoma. Peripheral blood and bone marrow biopsy were normal at the time of diagnosis, and some developed acute myeloid leukemia after 1 week and 7 months, respectively. Granulocytic sarcoma (granulocyticarcoma), also known as "green tumor", can be clinically seen in acute myeloid leukemia or chronic myeloproliferative disorders, and can also be diagnosed without any blood system disease. basic knowledge The proportion of illness: 0.003% Susceptible people: seen in women Mode of infection: non-infectious Complications: sepsis
Cause
Causes of vaginal granulocyte sarcoma
Cause:
The pathogenesis of vaginal granulosa sarcoma is still unclear.
Pathogenesis
Vaginal granulocyte sarcoma is diffuse homogenous infiltration, mainly composed of many immature bone marrow cells and a small number of bone marrow megakaryocytes. If eosinophilic immature cells are seen, it is highly suggestive for the diagnosis of this tumor. Electron microscopic observation, Giemsa staining Neutrophilic granules may be present in the cytoplasm. Histochemical peroxidase, chloroacetate and lysozyme are positive for histochemistry and immunohistochemistry. In addition, bone marrow mononuclear cells are synergistic antibodies, CD68 and CD43 are positive. .
Prevention
Vaginal granulocyte sarcoma prevention
1. Actively treat diseases such as vaginal leukoplakia, chronic inflammation and ulcers.
2. Anyone with irregular vaginal bleeding, abnormal leucorrhea, early diagnosis and active treatment.
3. After vaginal granulocyte sarcoma treatment should be adhered to 3 to 6 months of review, should be cytological examination, recurrence of vaginal bleeding or vaginal discharge should be treated at any time.
Early detection, early treatment, and good follow-up.
Complication
Vaginal granulocyte sarcoma complications Complications sepsis
Some patients have infectious sepsis. Sepsis: varies with the type, amount, virulence of the pathogen, and the age and resistance of the child. Lighter only has general symptoms of infection, and severe cases can occur with septic shock, DIC, and multiple organ failure. The total number of leukocytes in blood is significantly increased, reaching 10-30×109/L, and the percentage of neutrophils is increased, mostly above 80%, and there may be obvious nuclear left shift and intracellular poisoning particles. The number of white blood cells in a small number of Gram-negative sepsis and decreased immune function can be normal or slightly reduced. Neutrophil tetrazolium blue (NBT) test This test is only positive for bacterial infections, up to 20% or more (normally below 8%), contributing to viral infections and non-infectious diseases and bacterial infections. Identification.
Symptom
Vaginal granulocyte sarcoma symptoms Common symptoms Lower abdominal pain Menopausal vaginal bleeding
Vaginal granulocyte sarcoma is mainly characterized by vaginal bleeding or bleeding after menopause, vaginal discharge, may have lower abdominal pain. The vaginal mass is hard and confined to the skin or infiltrated into the surrounding pelvic tissue.
Because vaginal granulocyte sarcoma is rare, especially when peripheral blood and bone marrow examinations are normal, it is often difficult to make a diagnosis. If necessary, it can be diagnosed by electron microscopy.
Vaginal granulocyte sarcoma can be seen in relapsed acute myeloid leukemia, and can occur simultaneously with breast granulocyte sarcoma, as well as a report of acute myeloid leukemia by bone marrow biopsy due to vaginal granulocyte sarcoma.
Examine
Examination of vaginal granulocyte sarcoma
Blood routine examination, tumor marker examination, histochemistry and immunohistochemistry.
Colposcopy: vaginal granulocyte sarcoma is mainly characterized by vaginal bleeding or bleeding after menopause, vaginal discharge, may have lower abdominal pain. The vaginal mass is hard and confined to the skin or infiltrated into the surrounding pelvic tissue.
Diagnosis
Diagnosis and diagnosis of vaginal granulocyte sarcoma
Because vaginal granulocyte sarcoma is rare, especially when peripheral blood and bone marrow examinations are normal, it is often difficult to make a diagnosis. If necessary, it can be diagnosed by electron microscopy.
Vaginal granulocyte sarcoma should be distinguished from malignant lymphoma, vaginal cancer, and granulosa cell tumors.
