neuropeptide acroparesthesia
Introduction
Introduction to neuropeptide psychosomatic dysfunction The disease is a chronic pruritic, stinging skin disease that is confined to the hands and feet without a skin rash, and the cause is unknown. The course of the disease is chronic, the symptoms are not affected by temperature and emotional changes. In addition to the abnormal feeling of the extremities, the nerve and mental examination of the patient are normal. basic knowledge The proportion of illness: this disease is rare, the incidence rate is about 0.002% Susceptible people: no special people Mode of infection: non-infectious Complications: skin disease
Cause
Neuropeptide dysplasia
(1) Causes of the disease
The cause is unknown.
(two) pathogenesis
Direct immunofluorescence was performed to detect neuropeptide substance P, vasoactive intestinal peptide and calcitonin gene-related peptide, showing an increase in neuropeptide fibers in diseased skin.
Prevention
Neuropeptide-induced acne abnormality prevention
Mainly pay more attention to diet.
Complication
Neuropeptide dysplasia Complications
No relevant content.
Symptom
Neuropeptides, paresthesia, symptoms, common symptoms, thighs, tingling fingers or arm spurs...
The patient consciously had back and back of the hands and feet, itchy skin, tingling, local no obvious skin lesions, chronic disease course, symptoms are not affected by temperature, emotional changes, except for abnormal sense of the extremities, the patient's nerve and mental examination are normal, 1 : 10,000 histamine intradermal injection, erythema and pruritus reaction with the same control, ultraviolet (280 ~ 340nm) minimum erythema local exposure, 3 times a week for a total of 3 weeks, did not cause symptoms worse.
Examine
Examination of neuropeptide psychosynthesis
Histopathology: Direct immunofluorescence to detect neuropeptide P, vasoactive peptide and calcitonin gene-related peptide, showing an increase in neuropeptide fibers of the etiology of the skin.
Diagnosis
Diagnosis and differential diagnosis of neuropeptides
The disease is characterized by abnormal acral sensation without rash, and direct detection of neuropeptides, showing an increase in neuropeptide fibers in the lesion.
Should be identified with the itching point, the disease is limited to the bone protruding parts, the skin is itchy, spontaneous, lasts for a few minutes, hours or longer, local compression can relieve symptoms.
