ugly tire
Introduction
Brief introduction to ugly Harlequinfetus, also known as fetal ichthyosis (ichthrosisfetalis), is rare and is autosomal recessive, and the pathogenesis is still inaccurate. The child is covered with keratinous plaques at the time of birth, and the face is like a harlequin. Most of the children are stillbirths or die within a few days or weeks after birth due to breast milk and respiratory restriction. basic knowledge The proportion of the disease: the incidence rate is about 0.0001%-0.0003%, more common in premature infants Susceptible population: common in unborn fetuses Mode of infection: non-infectious complication:
Cause
Ugly cause
(1) Causes of the disease
It is autosomal recessive. The etiology of ichthyosis can be summarized into several major factors: genetic, mental, chemical, endocrine, infectious factors or external factors. It can be seen that the pathogenesis of this disease is multi-faceted, but it cannot be any factor or any part. Related to circulatory disorders, we are working hard to improve the microcirculation while studying therapeutic drugs.
(two) pathogenesis
The pathogenesis is still not very clear.
Prevention
Ugly prevention
The disease belongs to chromosomal diseases, and the cause of chromosomal abnormality is unclear. It may have certain correlation with environmental factors, genetic factors, dietary factors, and mood and nutrition during pregnancy. Therefore, this disease cannot be directly prevented. Early detection, early diagnosis, and early treatment are important for preventing this disease.
Complication
Ugly complication Complication
Most of the children are stillbirths or die after a few days or weeks of breathing due to breastfeeding.
Symptom
Ugly symptoms common symptoms
The child is covered with keratoconus plaques at birth, with a lack of or a hypoplasia of the auricles, a significant hernia, a lip valgus, an "O" mouth, and a ugly face. Most of the children are stillbirths or after birth. Because of sucking milk, breathing is limited to death within days or weeks.
Examine
Ugly check
Histopathology: excessive keratinization, a large number of angle plugs can be seen in the hair follicle and stratum corneum.
Diagnosis
Ugly diagnosis
According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed. Generally not confused with other diseases.
