multiple enchondromatosis
Introduction
Introduction to multiple endogenous chondromatosis Multiple endogenous chondromatosis was first described by Ollier in 1899 and is therefore also known as Ollier disease. It is a rare, non-hereditary benign tumor. Often the majority of asymmetrical distribution of cartilage lesions and subperiosteal deposits in the bone can occur in both long and short tubular bones, which can occur on one or both sides of the limb. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific people Mode of infection: non-infectious Complications: swelling
Cause
Multiple endogenous chondromatosis
(1) Causes of the disease
It is a part of the ectopic bone plate during bone development.
(two) pathogenesis
The tumor tissue is white, slightly shiny, brittle, translucent, doped with yellow calcification or ossification, or mucin-like degenerative zone. Microscopically, lobulated hyaline cartilage, chondrocytes piled up, with dual core The single core is uniform in size and not dyed deeply.
Prevention
Multiple endogenous chondromatosis prevention
The tumor tissue is white, slightly shiny, and crisp and translucent. Doped with yellow calcification or ossification zone, or mucus-like degeneration zone. Under the microscope, the lobulated hyaline cartilage chondrocytes were piled up, and there were binuclear ones. The size of the single nucleus was uniform and the staining was not deep. Multiple endogenous chondromas have the potential for malignant changes, and malignant transformation into chondrosarcoma or osteosarcoma should be noted.
Complication
Multiple endogenous chondromatosis complications Complications swelling
Can be combined with limb shortening, bending deformity, such as knee valgus. Minhang, the calf is short. It can be seen that the humerus arch deformity, the foot valgus, the external hemorrhoids disappear, and accompanied by other limb shortening deformities.
Symptom
Multiple endogenous chondromatosis symptoms Common symptoms Joint swelling Joint pain Unexplained fever
Usually the age of onset is less than 10 years old, more men than women.
Symptoms and signs: manifested as a palpable mass, but there is very little pain, the tumor invades the hands or feet, due to multiple lesions can cause sickness, lesions invade the long tubular bone, so that endogenous cartilage ossification can not be normal The epiphyseal plate can not grow normally, so the limb can be shortened and deformed, such as bending deformation of the forearm to the ulnar side, knee valgus of the lower limb, etc. When the patient reaches adulthood, the tumor can stop growing, and the endogenous chondromatosis can occur in adults. Malignant changes occur, and the rate of malignant transformation is about 5% to 25%.
Multiple endogenous chondromatosis, often in children with symptoms, to adolescent deformity is obvious, and gradually stabilized.
Examine
Multiple endogenous chondromatosis examination
X-ray examination: X-ray findings of each lesion with multiple endogenous chondromatosis are similar to single-end endogenous chondroma, but multiple, with skeletal deformities or shortening (Figures 1-3), the metaphysis can be Widening.
Diagnosis
Diagnosis and diagnosis of multiple endogenous chondromatosis
diagnosis
According to the history, clinical symptoms and signs, X-ray performance, general diagnosis is not difficult.
Differential diagnosis
Attention should be paid to the identification of synovial cysts, fibrous cortical bone defects, and metaphyseal dysplasia.
