Simple pulmonary eosinophilic infiltrates
Introduction
Introduction to simple pulmonary eosinophilic infiltration Simple pulmonary eosinophilic infiltration, also known as Loffler syndrome (Löffler's syndrome). It is characterized by migratory pulmonary infiltration with increased eosinophil count in peripheral blood, mild pulmonary symptoms, mostly only mild cough, and the course of disease is self-limiting, often healed within 3 to 4 weeks. basic knowledge The proportion of illness: 0.005% - 0.009% Susceptible people: no specific people Mode of infection: non-infectious Complications: chronic eosinophilic pneumonia
Cause
Causes of simple pulmonary eosinophilic infiltration
Causes:
This disease is likely to be a paralytic allergic reaction caused by parasitic infection and drug reaction, but about one third of the patients failed to find the cause, the disease is seasonally prevalent in some areas, so it is speculated that the environment is allergic It is also a possible cause in some areas.
Aphid infection is the most common cause of parasites. A variety of substances in aphid have strong antigenicity. Experiments have shown that after eating aphid eggs, the larvae migrate to the lungs and the typical lung manifestations and eosinophils can occur. High, other parasites causing the disease are hookworms, filarial worms, aphids, ginger worms, trichinella and amoeba, and drugs such as salicylic acid, aspirin, penicillin, nitrofurantoin, phenylbutazone, Chloropropionate, hydralazine, mecamylamine (mecamamine), sulfa drugs and methotrexate, sometimes inhaled pollen, fungal spores, etc. can also occur.
Pathogenesis:
Pathological changes are mainly located in the interstitial lung, alveolar wall and terminal bronchiole wall, with irregular eosinophil infiltration, and sometimes a cluster of eosinophils can be seen in the alveoli, rarely involving blood vessels.
Prevention
Simple pulmonary eosinophilic infiltration prevention
Pay attention to food hygiene, prevent infection with aphids, hookworms, filarial worms, aphids, ginger worms, trichinella and amoeba, etc.; use caution with salicylic acid, aspirin, penicillin, nitrofurantoin, phenylbutazone, chlorsulfuron Urea, hydralazine, mecamylamine, sulfa drugs and methotrexate.
Complication
Complications of simple pulmonary eosinophilic infiltration Complications chronic eosinophilic pneumonia
The disease can be asymptomatic, only found on X-ray examination; if symptoms are also very mild, the most common symptoms are cough, a small amount of sticky or a small amount of lemon sputum, occasional blood stasis, sputum contains eosinophils cell. In addition, there are headaches, fatigue, upper respiratory catarrh symptoms, night sweats, chest pain, etc., generally no fever, if there is low fever, occasionally high fever and wheezing, often return to normal within 1 to 2 days. Complications are not common.
Symptom
Symptoms of simple pulmonary eosinophilic infiltration common symptoms fatigue pharyngeal foreign body sensation chest tightness hernia chest tightness eosinophilia hemoptysis with fever
A small number can be asymptomatic, only occasionally found on X-ray examination, most patients have low fever, dry cough and chest tightness, occasionally hemoptysis.
Examine
Examination of simple pulmonary eosinophilic infiltration
1. Peripheral blood: white blood cells can be normal or slightly increased, eosinophil count is significantly increased, up to 10% to 20%, or 1000 to 2500/mm 3 .
2. Sputum examination: more eosinophils are often seen.
3. Pulmonary function test: manifested as mild to moderate restrictive ventilatory impairment, accompanied by decreased diffuse function.
4. Chest X-ray: The performance is often a light-density, unclear flaky shadow, distributed in the unilateral or bilateral lungs, showing a short walk, mostly disappeared in 1-2 weeks, but also in other parts appear.
Diagnosis
Diagnosis and diagnosis of simple pulmonary eosinophilic infiltration
According to clinical manifestations, peripheral blood eosinophils increased, eosinophils were seen in sputum and chest X-ray examination confirmed.
Generally not confused with other diseases.
