Acetaminophen poisoning
Introduction
Introduction to acetaminophen poisoning Acetaminophen (acetaminophen) has an antipyretic and analgesic effect. The drug is rapidly absorbed from the gastrointestinal tract, and the plasma concentration reaches the highest peak 30 to 120 minutes after oral administration (therapeutic amount). 90% of the drug is combined with glucuronic acid and sulfate in the liver and excreted from the urine; only 2% to 4% is metabolized by the intrahepatic cytochrome P-450 mixed functional oxidase system, becoming a toxic intermediate metabolite and Glutathione binding. After the latter is depleted, unbound metabolites bind to hepatocyte proteins, leading to hepatocyte necrosis. Hepatotoxicity can be produced by an oral administration of 7.5 g in an adult. basic knowledge The proportion of illness: 0.003% Susceptible people: no specific people Mode of infection: non-infectious Complications: abdominal pain
Cause
Cause of acetaminophen poisoning
Mainly due to excessive or ingestion of paracetamol, causing poisoning.
Prevention
Acetaminophen poisoning prevention
If the patient has an allergic reaction after taking the drug, stop taking it immediately; do not take it with other drugs containing acetaminophen; avoid drinking alcoholic beverages during medication; use liver and kidney dysfunction with caution, children under 3 years old and newborn Because of liver and kidney dysplasia, children should be avoided.
Complication
Acetaminophen poisoning complications Complications, abdominal pain
Can cause nausea, vomiting, sweating, abdominal pain and pale, etc., too much dose can cause liver damage, severe cases can cause coma, and even death.
Symptom
Acetaminophen poisoning symptoms Common symptoms Potential poisoning Astragalus nausea Hepatic dysfunction Renal failure Anorexia
Within 24 hours of taking the drug, the patient had mild anorexia, nausea, vomiting and sweating; the patient was consciously better 24 to 48 hours after taking the drug, but there was pain in the right upper abdomen liver area, and abnormal liver function, alanine and aspartate aminotransferase were found. Significantly increased; liver necrosis, hepatic encephalopathy, myocardial damage and renal failure occurred 2 to 4 days later, jaundice was obvious, and prothrombin time was significantly prolonged.
Examine
Examination of acetaminophen poisoning
Symptoms of poisoning should be immediately given to induce vomiting, gastric lavage, catharsis, enema and infusion, and then routinely checked after the condition is stable.
Diagnosis
Diagnosis and diagnosis of acetaminophen poisoning
diagnosis
Determination of drug plasma concentration can be found to be potentially toxic, repeated measurements after a few hours interval, to help diagnose the poisoning.
Differential diagnosis
It is mainly differentiated from drug poisoning that causes gastrointestinal reactions.
