Xinjiang hemorrhagic fever
Introduction
Introduction to Xinjiang hemorrhagic fever Xinjiang hemorrhagic fever (Xinjiang hemorrhagicfever; XHF) is a natural epidemic infectious disease caused by viruses and transmitted by hard palate. Clinically, it is characterized by fever, headache, hemorrhage, and hypotension shock. The pathogen of the disease is arbovirus RNA, which is round or elliptical. It has a capsule on the outside and has a diameter of 85-105 nm. It is classified into Bunyaviridae, Nairovirus, and the virus. It is the same virus as the Crimean-Congo hemorrhagic fever (CCHF) virus. It has pathogenicity to newborn mice, rats and golden hamsters, and can be used in the brains of suckling mice, chicken embryos and ground. Rat kidney, mouse kidney, milk rabbit kidney and Vero-E6 cells were propagated and cross-passaged, sensitive to lipid solvents, ether, chloroform, sodium deoxycholate, etc., for 90 minutes below pH 3.0, 30 minutes at 56 °C Can be inactivated, low concentration of formaldehyde can be inactivated to maintain its antigenicity, can be stored at 4 ° C for several years after vacuum drying. basic knowledge The proportion of sickness: 0.01% Susceptible people: no specific population Mode of infection: insect coal transmission Complications: hypoglycemia, hypertension
Cause
Causes of hemorrhagic fever in Xinjiang
The pathogen of the disease is arbovirus RNA, which is round or elliptical. It has a capsule on the outside and has a diameter of 85-105 nm. It is classified into Bunyaviridae, Nairovirus, and the virus. It is the same virus as the Crimean congo hemorrhagic fever (CCHF) virus. It has pathogenicity to newborn mice, rats and golden hamsters, and can be used in suckling mice and chicken embryos. Body, hamster kidney, mouse kidney, milk rabbit kidney and Vero-E6 cells are propagated and cross-passaged, sensitive to lipid solvents, ether, chloroform, sodium deoxycholate, etc., acting at pH 3.0 for 90 minutes, 56 °C can be inactivated in 30 minutes, low concentration of formaldehyde can be inactivated to maintain its antigenicity, can be stored at 4 ° C for several years after vacuum drying.
Prevention
Xinjiang hemorrhagic fever prevention
Flood control and mites are the main measures to prevent this disease. Lyme has a certain driving effect. The Shenzhou crown, radar aerosol and physiotherapy net have obvious smear effect, isolate patients and do personal protection work. .
Complication
Xinjiang hemorrhagic fever complications Complications hypoglycemia hypertension
Can lead to patients with fever, kidney failure, lung infection, hypoglycemia, high blood pressure and other complications.
Symptom
Xinjiang hemorrhagic fever symptoms common symptoms body pain chills oliguria high fever polyuria blood hot nose hypotension uterine bleeding hematuria
Incubation period 2 to 10 days, rapid onset, chills, high fever, headache, low back pain, generalized pain, thirst, vomiting, facial and chest skin flushing, conjunctival edema, soft palate and buccal mucosal bleeding points, upper chest, armpit, back There are bleeding spots and bleeding spots, there are nasal sputum, heat cycle about 1 week, hypotension shock before and after heat retreat, bleeding phenomenon, such as gastrointestinal bleeding, hematuria, uterine bleeding, etc., the course of about 10 to 14 days, no oliguria And the period of polyuria.
The diagnosis mainly relies on epidemiological data, including the history of effective pastoral or field work in epidemic areas, epidemic seasons, history of contact with sheep, rabbits, cattle, etc. or acute phase patients, history of ape bites, etc., clinical manifestations have acute onset, Chill, high fever, headache, low back pain, thirst, vomiting, bleeding on the mucous membranes and skin, obvious bleeding during the course of the disease and/or hypotension shock, laboratory tests for white blood cells and platelets decreased, lymphocytosis in the classification The presence of abnormal lymphocytes, complement fixation test, neutralization test and other double serum antibody titers increased by more than 4 times can be confirmed.
Examine
Xinjiang hemorrhagic fever examination
1. The number of white blood cells and platelets in the blood is reduced, the lymphocytes in the classification increase, there are abnormal lymphocytes, urine has protein, and the fecal occult blood test is mostly positive, bleeding, prolonged clotting time, and poor blood clot contraction.
2. The virus is isolated and the virus can be isolated from the blood of the early patient.
3. Serological tests include complement fixation test, neutralization test, reverse passive hemagglutination test, indirect immunofluorescence test, hemagglutination inhibition test, biphasic immunodiffusion test, etc., and the serum antibody titer is increased by more than 4 times. Diagnostic significance.
Diagnosis
Diagnosis and identification of hemorrhagic fever in Xinjiang
The disease should be differentiated from epidemic hemorrhagic fever, epidemic hemorrhagic fever has a certain prevalence area, clinically significant renal damage and five stages of the disease, serological tests can be distinguished.
