Bowenoid papulosis
Introduction
Introduction to Bowenoid papulosis This disease was first described by Lloyd in 1970. He called it a multi-centered pigmentary Bowen disease. Later, there were reversible female genital dysplasia, genital multi-center Bowen disease, and pigmented penile papules with in situ changes. It is recognized that the Bowenoid papulosis is more concise. This disease is characterized by multiple porcine rash in the genital area, benign, can subside, and the pathological tissue is cancerous in situ. basic knowledge The proportion of illness: 0.0025% Susceptible people: no specific people Mode of infection: non-infectious complication:
Cause
The cause of Bowen's papulosis
(1) Causes of the disease
Electron microscopic examination revealed that there were viral particles in the epidermal keratinocytes of the lesion.
(two) pathogenesis
Gross et al. used immunocytochemical techniques to find HPV structural antigens in the lesion tissue sections, and used HP hybridization technology to identify HPV-16-type related sequences.
Prevention
Bowen-like papulosis prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Bowen-like papulosis complications Complication
No special complications
Symptom
Bowen-like papulosis symptoms Common symptoms Pimples, genital warts, burning pain, itching, ring granuloma
The age of onset is 1 to 64 years old, and it is more common between 21 and 30 years old. The lesions are multiple or single pigmented papules with different sizes. The diameter is 2 to 10 mm. It is flesh-colored or reddish-brown and round. Oval or irregular shape, the boundary is clear, the surface of the papule can be bright and velvety, or the keratosis is mild, the skin lesions are scattered or clustered into a line or ring, and even can be fused into plaque, skin lesions. Occasionally occurs in the groin, external genital and perianal skin mucosa, males are more common in the penis and glans, women mostly occur in the size of the labia and perianal, generally no symptoms, some patients have itching or burning sensation, chronic disease, a few The patient's skin lesions can naturally resolve, but can recur.
Examine
Bowen-like papulosis examination
Pathological changes: typical Bowen's disease is characterized by disordered epidermal cells, many large nuclei, deep stains, piles of abnormally shaped squamous epithelial cells, and also keratinocytes, multinuclear and heteromorphic mitotic figures of keratinocytes, A small number of patients have coexistence of two pathological changes such as Bowenoid papules and condyloma acuminata at the same time or in the same lesion.
Diagnosis
Diagnosis and differentiation of Bowenoid papulosis
This disease is a benign morphological change, so it is often misdiagnosed as lichen planus, psoriasis, ring granuloma, pigmented papilloma, seborrheic keratosis, condyloma acuminata, etc., but there are special in situ squamous cell carcinoma tissue images. Can be identified.
The difference with Bowen's disease is that the disease is young, the skin lesions are frequent, and there is a tendency to pigmentation. However, Bowen's disease occurs mostly in the elderly. The lesion is often in the glans. It is a single large plaque, and the plaque slowly increases eccentrically. Big and infiltrated.
