Pseudohypoparathyroidism with Fibrocystic Osteitis
Introduction
Introduction to pseudohypoparathyroidism with fibrocystic osteitis Pseudohypoparathyroidism (PHPwithfibrocysticosteitis) with fibrocystic osteitis is a type of PHP that is relatively rare. The patient has hand, foot and ankle caused by hypocalcemia. The bones can be deformed and easily fractured. Treatment with vitamin D or its derivatives can restore normal blood calcium, followed by PTH to normal, bone disease healing. Treatment should be maintained for life. basic knowledge The proportion of illness: 0.0003% Susceptible people: no specific people Mode of infection: non-infectious Complications: fracture
Cause
The cause of pseudohypoparathyroidism with fibrocystic osteitis
(1) Causes of the disease
There is currently no relevant information.
(two) pathogenesis
The patient's kidney does not respond to PTH, the phosphorus is reduced, so there is hyperphosphatemia, PTH can not cause the kidney to produce 1,25-(OH)2D3, so the intestinal absorption of calcium is reduced, leading to hypocalcemia, hypocalcemia The disease causes an increase in PTH secretion, and PTH affects bone energy. Therefore, excessive PTH causes fibrocystic osteitis, so this disease is also called pseudo-hyperparathyroidism (pesudohypohyperparathyroidism).
Prevention
Prevention of pseudohypoparathyroidism with fibrocystic osteitis
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
Complication
Pseudohypoparathyroidism with fibrocystic osteitis Complications
The bones can be deformed and easily fractured.
Symptom
Symptoms of pseudohypoparathyroidism with fibrocystic osteitis Common symptoms Bone deformation shortens hand and foot tremor hypocalcemia
In most cases, there is no specific body shape of AHO. A few of them have this type. The patients have hand, foot and ankle caused by hypocalcemia, and the bones may be deformed and easily fractured.
Examine
Examination of pseudohypoparathyroidism with fibrocystic osteitis
The patient has hypocalcemia, hyperphosphatemia, increased alkaline phosphatase, and increased PTH. Exogenous PTH does not increase cAMP or phosphorus excretion in the kidney.
X-ray examination of the bone see fibrocystic osteitis.
Diagnosis
Diagnosis and diagnosis of pseudohypoparathyroidism with fibrocystic osteitis
Clinical symptoms of chronic hypocalcemia, signs, low blood calcium, high blood phosphorus, but the bones are manifested by parathyroidism, the diagnosis can be established.
1. Different from idiopathic hypoparathyroidism and PTH. The syndrome has a bone manifestation of parathyroidism.
2. Identification of the disease with hyperparathyroidism, low blood calcium, high blood phosphorus can be identified.
