Malignant lentigo
Introduction
Introduction to malignant freckles Malignant freckle-like sputum is a precursor of malignant melanoma, which is common in middle-aged and elderly people and occurs in skin that is often exposed to sunlight. The clinical manifestation is a brown or brown small spotted rash with a darker or lighter color. basic knowledge The proportion of illness: 0.005% Susceptible people: common in middle-aged and elderly people Mode of infection: non-infectious Complications: melanoma freckles
Cause
Malignant freckle-like cause
(1) Causes of the disease
Currently there are no related content description.
(two) pathogenesis
Epidermis atrophy, atypical melanocytes in the basal layer are non-nested hyperplasia, pigmentation deepens, anaerobic lymphocyte infiltration in the upper part of the dermis, mixed with some melanocytes, in the degenerative area of the lesion, epidermal melanin The cells are severely degenerated, and the dermis is mildly fibrotic, accompanied by infiltration of lymphocytes and melanocytes. When the atypical melanocytes proliferating on the basement membrane are nested or cord-like, and most of them are spindle cells, It has been shown to be an intradermal (in situ) melanoma and predicts that dermal invasion (invasive melanoma) is imminent.
Prevention
Malignant freckle-like prevention
Because the disease occurs in the skin that is often exposed to sunlight, it should be protected when going out during the summer season.
Complication
Malignant freckle-like complication Complications melanoma freckles
Malignant freckles can cause intracranial invasion and lung metastasis. The course of the disease is slow and can be in a relatively stable state within 20 to 30 years. If left untreated, it often breaks down and slowly invades deep tissues, especially on the face, which can damage the cartilage or bones in the nose, ears, eyelids and maxillary sinus, causing bleeding or intracranial invasion, but less regional Lymph node metastasis. Very few bloodways are transferred. Most of the metastases are lungs.
Symptom
Malignant freckle-like symptoms common symptoms freckle spot pigmentation
Onset, the lesion appears as a clear brown or brown small spotted rash, which can be slowly or rapidly expanded later. The original darker areas may become shallower, and even pigmentation may occur, while the shallower areas may deepen and form a color. Indistinct, irregularly shaped lesions, small macules, 3 to 5 mm in diameter, and large, usually >3 cm, occur in skin that is often exposed to sunlight. The macula rapidly expands, and the color changes, the shape should be considered when the disease is irregular, but the diagnosis requires pathological investigation.
Examine
Malignant freckle-like examination
Histopathological examination showed that the epidermis atrophy, and the atypical melanocytes in the basal layer showed non-nested hyperplasia and pigmentation.
Diagnosis
Diagnosis and diagnosis of malignant freckles
The disease should be distinguished from solar freckle-like sputum, junction sputum, seborrheic keratosis, pigmented basal cell carcinoma, pigmented solar keratosis, superficial spreading melanoma.
