Male Hyposexual Syndrome of Liver Cirrhosis
Introduction
Introduction to male dysfunction syndrome of cirrhosis Cirrhosis male sexual dysfunction syndrome, also known as endocrine deficiency-cirrhosis syndrome Silvestrini-corda syndrome. Its main clinical features are the appearance of male breast development, testicular atrophy and sexual dysfunction on the basis of cirrhosis. Intrinsic is more common, and there are far more men than women. In cirrhosis, due to the decreased inactivation ability of estrogen and the increased ability of androgen to convert into estrogen, the blood estrogen level and urine excretion increase, and the increase of estrogen level can inhibit hypothalamic-pituitary-gonads through feedback. The axis causes a decrease in the secretion of gonadotropin and adrenocorticotropic hormone, and a decrease in androgen secretion, which causes feminization in men. basic knowledge The proportion of illness: 0.0065% Susceptible people: male Mode of infection: non-infectious Complications: hepatic encephalopathy, primary liver cancer, liver and kidney syndrome, ascites
Cause
Etiology of male dysfunction syndrome in cirrhosis
In cirrhosis, due to the decreased inactivation ability of estrogen and the increased ability of androgen to convert into estrogen, the blood estrogen level and urine excretion increase, and the increase of estrogen level can inhibit hypothalamic-pituitary-gonads through feedback. The axis causes a decrease in the secretion of gonadotropin and adrenocorticotropic hormone, and a decrease in androgen secretion, which causes feminization in men.
Prevention
Prevention of dysfunction in male cirrhosis
The disease should actively prevent liver disease, and should be a reasonable diet, strengthen physical exercise, and enhance their own immunity.
Complication
Complications of cirrhosis male sexual dysfunction syndrome Complications hepatic encephalopathy primary liver cancer liver and kidney syndrome ascites
Because the disease is caused by cirrhosis, the disease can be accompanied by the following diseases:
1 Hepatic encephalopathy (hepatic coma): is the most common cause of death.
2 Upper gastrointestinal bleeding: Among them, the rupture of the fundus or esophageal varices caused by portal hypertension is common. Others such as hemorrhagic erosive gastritis, stomach, duodenal ulcer, and cardia mucosal tear syndrome are also causes of bleeding. one.
3 infection: patients with cirrhosis are prone to bronchitis, pneumonia, intestinal infection, spontaneous peritonitis and Gram-negative bacilli sepsis.
4 primary liver cancer: the relationship between liver cirrhosis and liver cancer is remarkable, it is speculated that the mechanism may be hepatitis B virus caused by hepatocyte damage secondary to hyperplasia or dysplasia, and the integration of hepatitis B virus and hepatocytes and immune function of liver cirrhosis patients Change and other factors are related.
5 hepatorenal syndrome: cirrhosis with persistent refractory ascites for a long time, or combined infection, the original liver disease aggravation and other factors, oliguria, no urine, azotemia, hyponatremia, low urinary sodium, the initial kidney often There is no organic disease, so it is called functional renal failure, and the prognosis of this complication is very poor.
Symptom
Hepatic cirrhosis male sexual dysfunction syndrome symptoms common symptoms loss of appetite fatigue jaundice testicular atrophy spider stagnation libido pain pain liver bloating
It is manifested as the gradual emergence of male breast enlargement on the basis of cirrhosis, which can be unilateral or bilateral, with the right side being more common, mild nipple or areola nodular bulge, and heavy like female breast, There is pain, but no milk secretion, in addition to male testicular atrophy, pubic hair is scarce, loss of libido, voice thinning, often accompanied by skin telangiectasia caused by spider mites and liver palm, female patients often do not show estrogen Obviously, there may be menstrual disorders, amenorrhea, infertility and functional uterine bleeding.
Examine
Examination of male dysfunction syndrome in cirrhosis
Blood routine and blood biochemistry, determination of serum E2, E3 levels increased, testosterone and its metabolites decreased.
Diagnosis
Diagnosis and identification of male dysfunction syndrome in cirrhosis
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
Note the differentiation from organic sexual dysfunction.
