tussah pupa encephalopathy
Introduction
Introduction to tussah moth encephalopathy Tussah encephalopathy is a central nervous system disease that occurs in the tussah breeding area and is induced by eating silkworm pupa. Intrinsic is a syndrome that was widely involved in the central nervous system of the extrapyramidal and cerebellum found in China in the 1980s. Since 1968, Wang Xiwei and other reports have reported 15 cases, there have been many cases reported. basic knowledge The proportion of illness: 0.0005%-0.0006% Susceptible people: no specific population Mode of infection: non-infectious complication:
Cause
The cause of tussah moth encephalopathy
(1) Causes of the disease
The cause is not completely clear, the patient has a history of eating silkworm cocoon, not silkworm mite degeneration, nor is it caused by mixed pesticides in silkworm cocoons, but only a few of the same or dozens of people with the same disease, so the incidence is related to individual differences. .
(two) pathogenesis
The pathogenesis of tussah moth encephalopathy is not clear. Some scholars believe that tussah is infected with "microparticle disease" before it is done, but it can continue to be transformed into sputum, and its protein has been decomposed and decomposed, and it produces toxins. The affinity of the virus acts on the susceptibility of the body and affects the central nervous system (Wang Xizhen, 1984); other scholars believe that the central nervous system may cause allergic reactions after eating the tussah pupa, which is an individual's Protein-sensitive, allergic encephalopathy (Tang Hongchuan et al., 2000).
Prevention
Tussah moth encephalopathy prevention
After the confirmed cases, the silkworm pupa should be stopped. The edible silkworm pupa should be fully heated. Those with a history of allergies should avoid eating.
Complication
Tussah silkworm encephalopathy complications Complication
Often combined with gastrointestinal symptoms and mental symptoms.
Symptom
Symptoms of tussah moth encephalopathy common symptoms gait instability tremor twitch muscle hypertonia coma nausea
1. Symptoms usually appear within 24 hours after eating tussah pupa, and gradually reach a peak, lasting for several days to more than ten days, and then slowly recovering, the general course of disease is a benign process.
2. The main clinical manifestations of this disease are dizziness, nausea, vomiting, tremors, gait instability and other symptoms. In severe cases, limb paralysis, urinary incontinence and coma, convulsions, etc., may also appear mental abnormalities: such as nonsense, illusion Listening, illusion and convulsions, etc. (Che Chengfu et al., 1989).
3. Check the eyelids, involuntary tremors of the eyeballs, face and limbs, unstable standing, difficulty walking, hemiplegia, coma, pathological reflex and meningeal irritation.
4. There is no correlation between the incidence and severity of the disease and the amount of silkworm cocoons.
Examine
Examination of tussah moth encephalopathy
1. Most patients have a slight increase in white blood cells, mainly granulocyte.
2. Lumbar cerebrospinal fluid pressure is generally normal, a small number of patients with protein and cell number can be increased, most patients have no significant changes.
3. A small number of patients with serum creatine kinase may have increased performance, which may be related to central nervous system involvement.
4. Most patients with EEG can have obvious abnormal changes, mainly manifested as extensive slow waves, many no focal changes and epileptic discharges.
5. There was no abnormal change in CT scan of the brain.
Diagnosis
Diagnosis and identification of tussah moth encephalopathy
1. Have a history of eating silkworm cocoons, and develop within 24 hours after eating.
2. First, dizziness, nausea, vomiting; then extrapyramidal symptoms such as increased muscle tone and ataxia such as tongue, face, muscle tremors and standing instability.
3. Severe people have slang, restlessness, auditory hallucinations, illusions and even coma.
4. If there is abnormal EEG, and there is no obvious abnormal change in cerebrospinal fluid and brain CT examination, diagnosis can be made.
The disease must be differentiated from organic mercury, organochlorine, organophosphate poisoning, posterior fossa lesions, viral encephalitis, acute cerebrovascular disease, Meniere's disease, and other extrapyramidal diseases.
