fibrosarcoma
Introduction
Introduction to fibrosarcoma A malignant tumor derived from mesenchymal tissue (including connective tissue and muscle) is called a "sarcoma." It occurs mostly at the skin, under the skin, periosteum and long bones. Such as fibrosarcoma grows rapidly, the tumor often has necrosis, hemorrhage, cut face gray red, uniform quality such as raw fish meat. Osteosarcoma is more common in young people, and it occurs at the two ends of the long bones of the extremities, especially at the lower end of the femur, the upper end of the humerus and the upper end of the tibia. Osteosarcoma develops rapidly and has a short course of disease. It begins to grow in the cortex and can gradually develop into the medullary cavity. Sometimes it breaks through the periosteum and invades the surrounding soft tissue, which may cause pathological fracture. Commonly, there are leiomyomas, lymphosarcoma, synovial sarcoma and the like. Hematogenous metastasis can occur early. Sarcoma is a malignant tumor. basic knowledge Sickness ratio: 0.0001% Susceptible people: no specific population Mode of infection: non-infectious Complications: soft fibroma
Cause
Cause of fibrosarcoma
Physical factors (40%):
Radiation factors may be related to the onset of fibrosarcoma. Radiation therapy for gynecologic tumors has been reported in China. After a certain interval, the fibrous tissue proliferation may occur in the abdominal wall of the patient. The local soft tissue thickens and infiltrates, some of which will continue to develop and eventually evolve into fibrosarcoma. Therefore, radiation factors may be one of the causes of the onset of fibrosarcoma.
Fibroma malignant (20%):
The onset of fibrosarcoma may also include malignant transformation of benign fibroma. Experts pointed out that benign fibromatosis, especially fibromatosis that grows in the palms and ankles, and ligament-like tumors that grow outside the abdominal wall and abdominal wall, infiltrate into the deep muscle layer. If not treated properly, it may recur due to repeated recurrence. Malignant transformation, causing the occurrence of fibrosarcoma.
Congenital factors (20%):
The onset of fibrosarcoma may also be related to congenital genetic factors. Although there is still controversy about this, children's congenital fibrosarcoma is very common and can usually be cured by local excision.
Prevention
Fibrosarcoma prevention
There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.
(1) Minimize infection and avoid exposure to radiation and other toxic substances, especially drugs that inhibit immune function; active virus and certain physical properties (such as radiation), chemical (such as anti-epileptic drugs, adrenal gland) The long-term application of corticosteroids may lead to abnormal proliferation of lymphoid tissue, which ultimately leads to lymphoma. Therefore, pay attention to personal and environmental hygiene, avoid drug abuse, and pay attention to personal protection when working in a harmful environment.
(2) Appropriate exercise, enhance physical fitness, and improve their disease resistance.
Complication
Fibrosarcoma complications Complications
It is prone to hematogenous metastasis and striated muscle fiber hyperplasia.
Symptom
Fibrosarcoma Symptoms Common Symptoms The smooth and rounded fascia of the foot and ankle is sore and soft on the outside of the leg. The waist is soft and hemispherical.
Local symptoms: local pain and swelling or accompanied by localized skin redness, hot joint effusion, pain or restriction of limb or joint activity.
Systemic symptoms: low heat and fatigue, physical discomfort, and dysfunction of related parts.
Examine
Fibrosarcoma examination
X-ray findings: mainly osteolytic lesions, strictly speaking, without any tumor osteogenesis, its image changes are large, no obvious features, its osteolytic range is large, the boundary is blurred, cortical bone fracture, invasion into soft tissue, There is little or no bone reaction in the periosteum. In some cases, fibrosarcoma can penetrate the cancellous and cortical bones, producing a "worm-like" image with less osteolysis and fusion.
Diagnosis
Diagnosis and diagnosis of fibrosarcoma
The imaging diagnosis of fibrosarcoma is at best a hypothesis because the image of fibrosarcoma resembles the image of all primary or metastatic malignant osteolytic tumors in adults.
The diagnosis of fibrosarcoma must rely on pathology. In histology, grade I fibrosarcoma may be difficult to distinguish from hard fibroids, but in fibrosarcoma, the nucleus is more, larger, fuller, and the staining is too deep and significantly more Shape, mitotic image, less collagen and less mature, fibrosarcoma and benign lesions, such as histiocytoma or fibrous dysplasia, histological distinction is easier, in addition to no malignant features, tissue cell fibroids It has a more obvious vortex-like structure, contains hemosiderin and giant cells, and occasionally foam cells; the fibrous structure is poorly bundled and contains characteristic woven bone islands.
