Acinar soft tissue sarcoma
Introduction
Introduction to alveolar soft tissue sarcoma Acinar soft tissue sarcoma refers to a soft tissue malignant tumor whose tissue source is unknown and the cells are acinar-like or organ-like. Christopherson first reported the disease in 1952. The disease occurs in adolescent women, with deep muscles or fascia in the extremities. The tumor grows slowly and is painless at an early stage. It can be transferred to the lungs, bones, brain, subcutaneous and other parts. The treatment was mainly surgical resection, and regular follow-up after surgery. Occurs in youth, more common in women, often located in the deep muscles or fascia of the extremities, a few can be found in the abdominal wall, anal area, tongue, retroperitoneum, neck and back, tumor growth is slow, early painless, often accidentally found, the diameter of the larger Up to 6 ~ 10cm, although the tumor block is not fast, but the blood circulation is rich, the superficial person can touch the pulsation, including metastasis to the skin, the tumor with a diameter of 1cm, the pulsation is also significant, and some patients can have extensive blood circulation. Mainly transferred to the lungs, bones, brain, subcutaneous and other parts, a small number of lymphatic metastasis, metastasis to the bone, along the long axis of the development of the bones clearly clear osteolytic destruction, no periosteal reaction, similar to the performance of some bone metastases. basic knowledge The proportion of sickness: 0.0045% Susceptible people: good for adolescent women Mode of infection: non-infectious Complications: osteosarcoma
Cause
The cause of alveolar soft tissue sarcoma
The alveolar soft tissue sarcoma was first reported by Christopherson in 1952. It is a malignant soft tissue tumor of unknown origin. Histopathological markers such as desmin and MyoD1 are expressed by pathological immunohistochemistry, and neurogenic markers such as S-100 and NSE are positive. It has been reported that its possible source is myogenic, which is a special type of rhabdomyosarcoma, but it is currently more controversial. In the 2002 classification of soft tissue tumors in WHO, it is still classified as a group of unidentified malignant soft tissue tumors.
Prevention
Alveolar soft tissue sarcoma prevention
Studies have shown that the recurrence rate of alveolar soft tissue sarcoma is 18.6% to 47.1%, and the metastasis rate is 35.3% to 75.8%]. If the incomplete resection, multiple recurrence or significant organ metastasis has a poor prognosis, prognosis and tumor The location, size, and complete surgical resection are related to the local resection of the tumor is the most important factor to prevent recurrence and metastasis. Postoperative prophylactic chemotherapy or radiotherapy has no obvious control effect on local recurrence and metastasis.
Complication
Complications of alveolar soft tissue sarcoma Complications osteosarcoma
The most common site of metastasis is the lungs, followed by the brain and bone.
Symptom
Symptoms of alveolar soft tissue sarcoma Common symptoms The lateral soft outer hemispherical mass of the leg is soft and semi... The round soft soft mass of the wrist is smooth and round.
Occurs in youth, more common in women, often located in the deep muscles or fascia of the extremities, a few can be found in the abdominal wall, anal area, tongue, retroperitoneum, neck and back, tumor growth is slow, early painless, often accidentally found, the diameter of the larger Up to 6 ~ 10cm, although the tumor block is not fast, but the blood circulation is rich, the superficial person can touch the pulsation, including metastasis to the skin, the tumor with a diameter of 1cm, the pulsation is also significant, and some patients can have extensive blood circulation. Mainly transferred to the lungs, bones, brain, subcutaneous and other parts, a small number of lymphatic metastasis, metastasis to the bone, along the long axis of the development of the bones clearly clear osteolytic destruction, no periosteal reaction, similar to the performance of some bone metastases.
Examine
Examination of alveolar soft tissue sarcoma
The alveolar soft tissue sarcoma can be used for CT, MRI and immunological examination, and the final diagnosis depends on tissue biopsy.
Diagnosis
Diagnosis and diagnosis of alveolar soft tissue sarcoma
Differential diagnosis and acinar rhabdomyosarcoma: small cells, deep nuclear staining, similar to lymphoblasts, rhabdomyosarcoma can be seen some cytoplasmic staining of red or long-banded rhabdomyoblasts, lack of sinusoidal network between acinar .
The tumor can be misdiagnosed as adenocarcinoma. The difference between the two is that the inner gland of the latter is relatively neat, and the cancer cells are arranged closely, which can show a certain polar direction and common secretions in the glandular cavity.
