reticulum cell sarcoma
Introduction
Introduction to reticular cell sarcoma Primary reticulum-cellsarcomaofbone is a primary bone tumor originating from bone marrow or cancellous bone. Although it is consistent with diffuse lymphoma-type reticulocyte sarcoma, it is a different disease, reticulocyte sarcoma. For localization, isolated bone lesions account for 5% of primary malignancies. The age of onset is the most common in 20-30 years old, children are rare, 50% of cases are related to 40 years old, and there are also cases of 40 years old or older, the ratio of male to female is 2:1. Any bone can be invaded, but the most common femur, tibia and fibula. One third occurred around the knee joint. The humerus accounts for about 9%, and flat bones such as the hip bone, scapula, and spine often occur. basic knowledge Sickness ratio: 0.0001% Susceptible people: 20 to 30 years old Mode of infection: non-infectious Complications: bone tumor liver tumor
Cause
Reticular cell sarcoma etiology
The cause of this disease is unknown, some scholars believe that it may be related to the environment and heredity, but there is no conclusive evidence.
Prevention
Reticular cell sarcoma prevention
Without effective preventive measures, early diagnosis and early treatment are the key.
Complication
Reticular cell sarcoma complications Complications, bone tumor, liver tumor
This tumor tends to metastasize to other bones, regional lymph nodes, distant lymph nodes, liver, spleen and kidneys.
Symptom
Reticular cell sarcoma symptoms Common symptoms Bone pain simple fracture lymph node enlargement
The main symptoms are local pain, rest can not be relieved, but some patients have only mild intermittent pain. The clinical feature is that although the bone destruction is serious, the general condition is still good. Although the pathological fracture of this disease is the most common in malignant bone tumors, the vertebrae Body collapse can cause severe neurological dysfunction, but natural history suggests that its prognosis is much better than diffuse reticulum sarcoma, which tends to metastasize to other bones, regional lymph nodes, distant lymph nodes, liver, spleen and kidney Lung metastasis is rare, but it does exist.
Examine
Examination of reticular cell sarcoma
X-ray findings are not characteristic. Although they are now diverse, they are usually mainly characterized by focal destruction of bone. Whether long bone or flat bone is in the bone marrow cavity or cancellous bone, penetrating, speckled destruction zone is formed. A wide range of osteolytic defects, the last cortical invasion, the metaphyseal lesions occur earlier than the backbone, the cortex is more eroded or perforated, the medulla has a wider infiltration, visible periosteal reaction, but not seen in Juventus The obvious onion skin-like changes in sarcoma, in some cases, the only X-ray manifestation is a lamellar or solar-like periosteal reaction, the reactive new bone can be obvious, or the tumor is completely destroyed.
Diagnosis
Diagnosis and diagnosis of reticulocyte sarcoma
In histology, it should be differentiated from lymphoma-type reticulocyte sarcoma. The main component is a piece of cells. The nucleus is quite large, spherical, occasionally nucleoli, easy to find the dividing phase, some cell boundaries are clear, sharp, cytoplasm Rich, white, nuclear shape can be jagged, intercellular reticular fibers seem to surround the cells, reticular fiber staining negative for silver staining is characteristic, however, some tumors can lack reticular fibers, so can not be diagnosed alone.
In general, it should be differentiated from Ewing's sarcoma. Some reticulocyte sarcomas diffuse cell proliferation. These cells can be poorly differentiated lymphocytes or lymphoid-tissue cells. The nucleus is usually larger and rounder than Ewing's sarcoma. The latter has a clear outline, but Ewing's sarcoma lacks reticular fibers and has glycogen in the cytoplasm to distinguish it.
