neurofibrosarcoma
Introduction
Introduction to nerve fiber sarcoma Neurofibrosarcoma is a rare tumor, accounting for 5% to 10% of malignant soft tissue tumors. The age of onset is more common in young and middle age. The most common sites are in the head and neck, buttocks, limbs and retroperitoneal, etc., and can also occur in the back, abdominal wall and mediastinum. Generally, it is a painless tumor mass, which is not developed rapidly. In some cases, there is pain in the affected limb, and then the tumor and affected neurogenic dysfunction occur. Local tenderness, 40% of cases with neurofibromatosis. Because of the mild symptoms, the tumors are larger when coming to the clinic, and most of the long diameters are above 10cm. Malignant neurofibroma is more common in the proximal torso of the trunk, originating from the peripheral nerve sheath, and can also be malignant by neurofibroma. The nuclear fibrosis of the tumor cells of neurofibromatosis is irregular, the staining is extremely concentrated, and the giant cells and mitotic figures of the tumor are seen. There is a small amount of lymphocyte infiltration in the stroma. If malignant neurofibroma is not treated with chemotherapy, bioimmunotherapy can be used to kill tumor cells while inhibiting the further spread of tumor cells. The effect of ascites on the deterioration of tumor properties is obvious. basic knowledge The proportion of sickness: 0.002% - 0.008% Susceptible people: no special people Mode of infection: non-infectious Complications: cerebrospinal fluid leakage
Cause
Cause of neurofibrosarcoma
Cause:
Malignant neurofibroma is more common in the proximal torso of the trunk, originating from the peripheral nerve sheath, and can also be malignant by neurofibroma. The nuclear fibrosis of the tumor cells of neurofibromatosis is irregular, the staining is extremely concentrated, and the giant cells and mitotic figures of the tumor are seen. There is a small amount of lymphocyte infiltration in the stroma. If malignant neurofibroma is not treated with chemotherapy, bioimmunotherapy can be used to kill tumor cells while inhibiting the further spread of tumor cells. The effect of ascites on the deterioration of tumor properties is obvious.
Prevention
Neurofibrosarcoma prevention
There is no effective preventive measure for this disease, and early diagnosis and early treatment are the key. Neurofibrosarcoma prevention can prevent tumors as long as it is the best in normal life.
1. Strengthen physical exercise, enhance physical fitness, and exercise more in the sun. Excessive sweating can excrete acidic substances in the body with sweat, avoiding the formation of acidic constitution. Have a good attitude to cope with stress, work and rest, do not fatigue. Visible pressure is an important cause of cancer. Chinese medicine believes that stress leads to excessive physical weakness, which leads to decreased immune function, endocrine disorders, metabolic disorders in the body, leading to the deposition of acidic substances in the body. Stress can also lead to mental stress causing qi stagnation and blood stasis. Invagination and so on.
2. Don't eat too much salty and spicy food, don't eat food that is overheated, too cold, expired and deteriorated; those who are frail or have certain genetic diseases should eat some anti-cancer foods and high alkali content as appropriate. Alkaline foods, maintain a good mental state to develop good habits, stop smoking and limit alcohol. Smoking, the World Health Organization predicts that if people no longer smoke, after five years, the world's cancer will be reduced by 1/3; secondly, no alcohol. Smoke and alcohol are extremely acidic and acidic substances. People who smoke and drink for a long time can easily lead to acidic body. Finding timely treatment of the disease is key.
Complication
Neurofibrosarcoma complications Complications cerebrospinal fluid leakage
1. Epidural hematoma: paravertebral muscles, vertebrae and dural venous plexus are not completely hemostasis, hematoma can form after operation, resulting in limb paralysis, which occurs within 72 hours after surgery, even in the case of drainage tube Hematoma can also occur. If this phenomenon occurs, it should be actively explored to remove the hematoma and completely stop bleeding.
2. Spinal cord edema: often caused by surgical operation of the injured spinal cord, clinical manifestations similar to hematoma, treatment with dehydration, hormones, severe cases can be operated again, open dura.
3. Cerebrospinal fluid leakage: mostly caused by the dural and muscle layer suture is not tight, if there is drainage, the drainage tube should be removed in advance. If the leakage is less, the drug change can be observed. If the leakage cannot be stopped or the leakage is excessive, the fistula should be sutured in the operating room.
4. Incision infection and rupture are generally poor, and the wound healing ability is poor or cerebrospinal fluid leakage is easy to occur. Intraoperative attention should be paid to aseptic operation. In addition to antibiotic treatment, it should actively improve the general condition, paying special attention to the supplement of protein and multivitamins.
Symptom
Neurofibrosarcoma Symptoms Common Symptoms Persistent Pain Cystic Masses
The age of onset is more common in young and middle-aged people. The most common sites are in the head and neck, buttocks, limbs and retroperitoneum. It can also occur in the back, abdominal wall and mediastinum. It is usually a painless tumor mass. It is not developed quickly. Some cases are first. There is pain in the affected limb, and then the tumor and affected neurogenic dysfunction, local tenderness, 40% of cases with neurofibromatosis, due to mild symptoms, more tumors at the time of diagnosis, most of the long diameter is more than 10cm.
Examine
Examination of neurofibrosarcoma
1. Generally observed, the tumor has a large nerve trunk attached to it, but the neurofibrosarcoma belongs to the unknown nerve, so there is no nerve to find, the lesion is deeper, like other sarcomas, the cut surface is grayish white, may be accompanied by bleeding. Necrosis.
2. Microscopic examination showed malignant Schwann cells. The tumor cells were fusiform, the nucleus was deeply stained, the size was uneven, and the mitotic figures were seen. Epithelioid Schwann cells were also seen. The tumor cells were round and multi-deformed. The pulp is somewhat different, powdered in granular form, arranged in a nest of solid nests, and also has an acinous or cord-like structure.
Diagnosis
Diagnosis and diagnosis of neurofibrosarcoma
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
Mainly differentiated from fibrosarcoma, fibrosarcoma cells are fusiform, interlaced, with obvious atypia, but no nuclear grid-like arrangement, the tumor is not associated with the nerve trunk.
