chondromyxoid fibroma
Introduction
Introduction to cartilage myxoid fibroma Chondromyxoid fibromaofbone is an uncommon benign tumor that originates from the connective tissue that forms cartilage and is easily confused with chondrosarcoma or cartilage sarcoma. Although from the histomorphology, there are both cartilage-like tissues in the tumor, and there are megakaryocytes in the mucus-like substance formed between the small round cells or cells with strange nucleus shapes, but the development of the tumor is slow and manifests as a benign process. Clinically, the symptoms are mild, and there is generally no recurrence after surgery, and there is less metastasis. basic knowledge The proportion of sickness: 0.04% - 0.06% Susceptible people: The disease occurs in adolescents, and there is no difference between men and women. Mode of infection: non-infectious Complications: chondrosarcoma
Cause
Cause of cartilage myxoid fibroma
Cause:
It originates from the connective tissue that forms cartilage and has mucin-like and cartilage-like characteristics. Age and gender distribution, according to the literature, the minimum 4 years old, the largest 79 years old, the most common 10 to 30 years old, accounting for 72%. Age has no effect on the location of the disease. More men than women, 1.9:1. Related to age, gender, environment, genetics, trauma and other factors.
Prevention
Chondromyxoid fibroma prevention
1. Maintain an optimistic and happy mood. Long-term mental stress, anxiety, irritability, pessimism and other emotions will make the balance of the cerebral cortex excitatory and inhibition process imbalance, so you need to maintain a happy mood.
2, life restraint pay attention to rest, work and rest, life orderly, maintain an optimistic, positive, upward attitude towards life. Do the regularity of tea and rice, live daily, not overworked, open-minded, and develop good habits.
3, reasonable diet can eat more high-fiber and fresh vegetables and fruits, balanced nutrition, including protein, sugar, fat, vitamins, trace elements and dietary fiber and other essential nutrients, meat and vegetables, diversified food varieties, Give full play to the complementary role of nutrients in food.
Complication
Complications of cartilage myxoid fibroma Complications chondrosarcoma
It is easy to relapse after surgery, and in many cases, it can be changed to chondrosarcoma.
Symptom
Symptoms of cartilage myxoid fibroma Common symptoms Bone pain Spontaneous fracture Long bone swelling Pain
The disease occurs in adolescents, there is no difference between men and women, 80% of cases are seen below 30 years old, and children under 10 years old are rare, more common in the lower limbs, especially the upper end of the humerus, the lower end of the femur and tibia, and some occur in the humerus, calcaneus , ribs and hip bones, individual cases also involve the spine, lesions are mostly located near the metaphysis, in the long bones, the tumors are mostly eccentric, and can invade and destroy the local cortical bone. In the short tubular bone, the tumor completely occupies the medullary cavity. And caused local swelling changes, clinical symptoms are mild, mainly local pain, swelling, some patients have no discomfort, after the trauma, the tumor was found by the film.
Examine
Examination of cartilage myxoid fibroma
Film degree exam
Tumors located in long bones are often involved in the metaphysis, ovoid or round osteolytic lesions that grow eccentrically, grow outward, bulge, clear edges, harden, and may also have focal margins, such as continued growth, bone The shell is shallow, but there is no new bone formation. The diameter of the tumor is 1-10cm, with an average of 3cm. The cortical bone of the lesion is thin and swelled, there is no periosteal regeneration, the marginal cortical bone disappears and destroys, and the sinus and soft tissue can break through the marginal bone. The cortex was picked up in a disk shape, and a small Codman triangle appeared. Tumor calcification was rare on the X-ray, but 1/4 of histological observations revealed calcification, and pathological fractures were rare.
Pathological change
Observed lesions similar to fibrocartilage, round or elliptical or lobulated, with a white face, clear edges, hard and elastic, no trabecular bone and bone streaks in the lesion, no obvious mucus-like tissue, occasionally calcification point.
Under the microscope, the tumor components include fibrous tissue, mucous tissue and cartilage tissue. The early mucus tissue is the main component, and some of the cells are loose or dense, and are irregularly lobulated. The tumor cells in the lobular are fusiform or dense. Irregular lobulated, the tumor cells in the lobular are fusiform or star-shaped, the nucleus is stained deeply, the mucinous cells are mucus, but the staining is negative, the lobular marginal tumor cells are very dense, the blood vessels are rich, the nucleus is large, and there may be Two-core, multi-nuclear, can have old bleeding, mucus can be fibrotic, or evolve into cartilage-like tissue, in large fibrous tissue, can be seen in cartilage islands of different sizes.
Diagnosis
Diagnosis and identification of cartilage myxoid fibroma
Differential diagnosis
(a) giant cell tumor
More common in the epiphysis area, the local cortex is obviously swelled and thinned, mainly due to osteolytic destruction, and there may be multiple interlaced linear interstitial spaces, sometimes showing a typical foamy shape, which is prone to pathological fractures.
(two) bone cyst
The upper end of the humerus and the upper end of the femur are more common. The tumor is located in the center of the metaphysis and expands to the surrounding. The translucent area is more uniform, and the bone interval of the multi-atrial bone cyst is also fine.
