Kaposis Sarcoma
Introduction
Introduction to Kaposis sarcoma KS is a representative disease of AIDS malignant tumors. The clinical features of KS: skin idiopathic, multiple, pigmented sarcoma, is considered to be a local and frequently-occurring disease in the equatorial region of the African continent. In men, most of the nodules of different sizes occur in the extremities. Later generations call this disease Kaposis sarcoma. Tumor nodules are composed of spindle cells and small blood vessels. This damage is in the middle and lower layers of the dermis. It can form ulcers on the epidermis, which can invade the bone. Hemorrhage and hemosiderin can sometimes be seen in the nodules. There may be small lymphatic vessel dilatation, lymphocytic infiltration, plasma cell reaction and granulation hyperplasia. The shape is very irregular. Sometimes there may be lymphangiosarcoma, hemangiopericoma and multiple glomus tumors in tiny Kaposis sarcoma. . basic knowledge The proportion of illness: 0.005% Susceptible people: good for middle-aged men Mode of infection: non-infectious Complications: osteosarcoma
Cause
Cause of Kaposis sarcoma
Cause:
Tumor nodules are composed of spindle cells and small blood vessels. This damage is in the middle and lower layers of the dermis. It can form ulcers on the epidermis, which can invade the bone. Hemorrhage and hemosiderin can sometimes be seen in the nodules. There may be small lymphatic vessel dilatation, lymphocytic infiltration, plasma cell reaction and granulation hyperplasia. The shape is very irregular. Sometimes there may be lymphangiosarcoma, hemangiopericoma and multiple glomus tumors in tiny Kaposis sarcoma. .
Prevention
Kaposis sarcoma prevention
Safe sex prevents HIV infection and prevents AIDS and its complications, including Kaposi's sarcoma.
Complication
Kaposis sarcoma complications Complications osteosarcoma
Even after a significantly successful treatment, the tumor may still recur, and for AIDS patients, Kaposi's sarcoma may be fatal.
Symptom
Symptoms of Kaposis Sarcoma Common symptoms Red or purple, slightly... Crimson papules pruritus rash around the upper lip, nasal side... Conjunctival edema and corneal ulcer White halo Oral mucosal ulcer Ulcer pain Lymph node enlargement
KS infringes on a wide range of parts, limbs, face and trunk, skin can appear, oral mucosa, eyelids, mucous membranes also occur, in addition, lung, liver, spleen and other organs, especially when the digestive tract is prone to major bleeding Danger.
Clinical manifestations:
1 Nodular type: cherry red or purple, the surface is smooth, highlights the surface of the skin, the boundary is clear, the quality is hard, the pressure can make it shrink in size, and the original state is restored within 10 seconds after relaxation. This sign is called Hayne's sign, and the nodule can be It is distributed throughout the body, but it is most common in the lower limbs, feet and forearms. The typical lesions are easy to bleed, but there is no pain. Most of the patients are elderly, and the survival period after the disease is about 10 years.
2 Infiltration type: skin lesions merge with each other, ulcer or verrucous hyperplasia, often involving subcutaneous and bone tissue. This type occurs mostly in the lower limbs and feet. There are nodules in the lesions. This type progresses fast and the survival period does not exceed 3. year.
3 Pan-type: refers to the extensive invasion of internal organs, such as the gastrointestinal tract, liver, spleen, respiratory tract and lymphoid tissue, except for lesions. When lymphatic tissue is invaded, it can be called lymphoid adenoid Kaposis sarcoma. It only accounts for about 5% of all cases, but the disease develops rapidly and the prognosis is poor. It is often life-threatening due to major bleeding.
Examine
Examination of Kaposis sarcoma
(1) Depletion of CD4+ T lymphocytes: T lymphocyte function decreased, peripheral blood lymphocytes decreased significantly, CD4<200/l, CD4/CD8<1.0, negative-type allergic skin test was negative, and mitogen stimulation was low.
(2) B lymphocyte dysfunction: polyclonal hyperglobulinemia, circulating immune complex formation and autoantibody formation.
(3) NK cell activity decreased.
Diagnosis
Diagnosis of Kaposis sarcoma
Identification with lymphangiosarcoma, lipoma, spindle cell lipoma, liposarcoma, non-Hodgkin's lymphoma.
