maxillofacial neurofibromas
Introduction
Introduction to maxillofacial neurofibroma The maxillofacial neurofibromatosis is a benign tumor composed of two main components: nerve sheath cells and fibroblasts. It is divided into two types: single and multiple types. Multiple neurofibromas, also known as neurofibrosis, can occur around the tumor. In any part of the nerve, the oral and maxillofacial diseases often occur in the trigeminal and facial nerves, usually located in the face, ankle, eyes, neck, tongue and ankle. basic knowledge The proportion of illness: 0.05% - 0.08% Susceptible people: more common in young people Mode of infection: non-infectious Complications: sarcoidosis
Cause
The cause of maxillofacial neurofibromatosis
Cause:
The NFI genome spans 350Kb, cDNA is 11Kb in length, contains 59 exons, encodes 2818 amino acids, and constitutes a 32kD neurocellulose protein distributed in neurons. The NFI gene is a tumor suppressor gene, translocation, deletion, rearrangement or In the case of point mutation, tumor suppressor function is lost and pathogenic, and NFII gene deletion mutation causes Schwann cell tumor and meningioma.
Prevention
Maxillofacial neurofibroma prevention
It is very important to maintain a good attitude, to maintain a good mood, to have an optimistic, open-minded spirit, and to be confident in the fight against disease. Don't be afraid, only in this way can you mobilize your subjective initiative and improve your body's immune function.
Complication
Maxillofacial neurofibromatosis complications Complications
Adults with faster development and larger skin lesions have a poor prognosis due to malignant transformation.
Symptom
Symptoms of maxillofacial neurofibroma Common symptoms Pigmented facial deformity nodules are vague, emotional facial pain, long ears, slow growth
1. More common in young people, slow growth.
2. Unclear border, soft texture, sagging, facial deformity, incompressible.
3. The tumor can be licked and beaded or plexiform nodules.
4. The skin is scattered in pigmented spots.
5. Multiple people can have a family history.
6. Can have a family history.
Examine
Examination of maxillofacial neurofibroma
Histopathological examination confirmed
1. For the clinical manifestations are more typical, the preoperative diagnosis has been more clear to check the project to check the box limit "A".
2. For the atypical clinical manifestations, the differential diagnosis or the large tumor examination program may include the check boxes "B" and "A".
Diagnosis
Diagnosis and diagnosis of maxillofacial neurofibroma
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
It should be differentiated from nodular sclerosis, syringomyelia, and local soft tissue hemangioma of bone dysplasia syndrome.
