malignant fibrous histiocytoma of bone
Introduction
Introduction of malignant fibrous histiocytoma of bone Malignant fibrous histiocytoma (MFH) often occurs in deep soft tissues, and is rarely seen in the bone. In the past, malignant fibrous histiocytoma of bone was often misdiagnosed as osteosarcoma, fibrosarcoma, giant cell tumor of bone or metastatic carcinoma of the bone. Feldman and Norman proposed in 1972 a malignant fibrous histiocytoma of the bone as an independent type of bone tumor. The disease is slow onset, mostly in middle-aged and older people, more men than women, more common in the lower end of the femur and the metaphysis of the upper end of the tibia. Clinical manifestations of local pain and swelling. Surgery plus chemotherapy is the main treatment. The disease has high malignancy and poor prognosis. basic knowledge The proportion of illness: 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: lung metastases
Cause
Cause of malignant fibrous histiocytoma of bone
The cause of the disease is still unclear, and there are familial reports; the occurrence of tissue is still unclear, and it is believed that the histiocytes and fibroblasts in the pathological tissues are derived from unified cells, undifferentiated mesenchymal cells.
Pathological change
(1) Generally seen
The tumors were all osteolytic grayish white, accompanied by scattered hemorrhage, necrotic foci, showing a gray-red or gray-brown color, and a few cystic changes occurred.
(2) less under the microscope
The tumor is composed of interstitial tissue cells and fibroblasts. Currently, there are benign and malignant multinucleated giant cells and inflammatory cells. There is no calcification. The tissue cells are round or nearly circular, and the nucleus is round or kidney-shaped. It has obvious heteromorphism, is rich in cytoplasm, and has phagocytosis. The foam cells contain cell debris and hemosiderin. The fibroblasts are dense and dense, and the cells are arranged in a spiral or car-like manner. Large, oval, nuclear apparently heteromorphic, multinucleated giant cells have benign and malignant, the former is very similar to osteoclasts or Touton giant cells, malignant tumor cells.
Prevention
Malignant fibrous histiocytoma prevention of bone
1. Maintain an ideal weight.
2. Ingest a variety of foods.
3. The diet includes a variety of vegetables and fruits.
4. Ingest more high-fiber foods (such as whole grain cereals, beans, vegetables, and fruits).
5. Reduce total fat intake.
6. Limit the intake of alcoholic beverages.
7. Limit the intake of pickled, smoked, and nitrite-containing foods.
Complication
Bone malignant fibrous histiocytoma complications Complications
Lung, liver, brain and other metastases can occur and die.
Symptom
Symptoms of malignant fibrous histiocytoma of the bone Common symptoms Long bone swelling, pain, bone pain, poor fibrous structure
Malignant fibrous histiocytoma is a rare disease with moderate age and old age. Males are slightly more than females, about 10:8. The most common sites are the lower end of the femur and the upper end of the humerus. Symptoms are localized pain and swelling, and the onset is slow, from weeks to months.
Examine
Examination of malignant fibrous histiocytoma of bone
X-ray performance
The lesion is a translucent area with a foci-like defect. It has a complete margin and occurs in the metaphysis. Cortical destruction is often seen and penetrates into the soft tissue. There is no obvious periosteal reaction. X-ray signs are similar to other primary or subsequent Malignant tumors, no characteristic, whole body bone scan and CT examination help the identification of tumors as intramedullary or extra-osseous.
Diagnosis
Diagnosis and diagnosis of malignant fibrous histiocytoma of bone
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
In imaging, it must be differentiated from fibrosarcoma, osteolytic osteosarcoma, lymphoma, osteolytic bone metastasis, and histologically, fibrous fibroids (multiple spindle cells, tibial-like structures), osteosarcoma (neoplastic osteogenesis) identification, similar to the malignant fibrous histiocytoma area seen in fibrosarcoma and osteosarcoma, further study, in the case of the diagnosis of malignant fibrous histiocytoma is not certain or unclear, the diagnosis must be based on Adequate and large number of histological sections. In addition, the histological differential diagnosis of malignant fibrous histiocytoma also includes bone metastasis of cancer. Their longer cells are arranged in a fuzzy lamellar structure, while the cells of malignant fibrous histiocytoma are also It may have an epithelial appearance and may aggregate into a group of vesicles.
