dedifferentiated chondrosarcoma
Introduction
Introduction to dedifferentiated chondrosarcom Dedifferentiated chondrosarcoma can be found in cases of recurrence and metastasis, as well as in primary tumors coexisting at different malignant levels. In central chondrosarcoma, progression from grade I central chondrosarcoma to grade II central chondrosarcoma is rare, even if it occurs slowly, and grade I central chondrosarcoma can retain its multiple relapses and years of disease. The degree of malignancy remains unchanged. The development of grade II central chondrosarcoma to grade III central chondrosarcoma can be rapid and not uncommon. Sometimes a more malignant tumor is produced in grade I or II central chondrosarcoma, which is histologically malignant fibrous histiocytoma, fibrosarcoma, osteosarcoma and angiosarcoma. These tumors were defined as "anti-differentiated chondrosarcoma", 15% of cases of dedifferentiated chondrosarcoma, and patients were older than those with central chondrosarcoma, usually after age 50. basic knowledge The proportion of illness: 0.002% Susceptible people: more common after the age of 50 Mode of infection: non-infectious Complications: chondrosarcoma
Cause
Dedifferentiated chondrosarcoma etiology
There are two distinct tumor tissues, one is a well-differentiated cartilage tumor, and the histopathology may vary between cases. The histological manifestations from chondroma to grade III chondrosarcoma may exist in the same case, most cases It is characterized by grade I or II central chondrosarcoma, and the other is malignant tumor tissue, usually malignant fibrous histiocytoma, osteosarcoma and fibrosarcoma. This tumor tissue is characterized by high malignancy. The process of transforming tumor tissue into another tumor tissue is not continuous.
Dedifferentiated chondrosarcoma must be distinguished from grade III central chondrosarcoma. There are undifferentiated cells around the central chondrosarcoma lobules. There is a gradual transformation between these cells and chondrocytes. Dedifferentiated chondrosarcoma should also be associated with mesenchymal chondrosarcoma. Separately, mesenchymal chondrosarcoma has small undifferentiated cells in which scattered cartilage islands are scattered.
Prevention
Dedifferentiated chondrosarcoma prevention
Prevention method:
1. Ingest enough nutrients and eat high-protein, high-sugar, multi-vitamin diets. Diet should be light and easy to digest.
2. Pay attention to rest and proper activities.
3. Keep your mood happy and not angry.
Complication
Dedifferentiated chondrosarcoma complications Complications chondrosarcoma
Dedifferentiated chondrosarcoma often metastasizes.
Symptom
Dedifferentiated chondrosarcoma symptoms Common symptoms Extramedullary bones, long bones, swelling, pain
The medical history can be very long, with moderate symptoms, then rapid progressive pain and swelling, swelling can be expanded to soft tissue, in other cases, the initial symptoms can be symptoms of malignant sarcoma without any precursors; or It is manifested by pathological fractures.
Examine
Examination of dedifferentiated chondrosarcoma
X-ray findings of primary cartilage lesions usually manifest as moderate swelling of the bone, thickening of the cortical bone, obvious bone boundary, typical calcification in the tumor, progressive lesions showed progressive osteolytic lesions, a few for progressive Osteogenic lesions, the original calcification disappears, cortical bone destruction, invasion of soft tissue, and sometimes, only a new progressive tumor, its radiological image is similar to various malignant osteolytic tumors in adulthood, only obtained from the previous X-ray films and/or histological examination of the entire tumor can reveal traces of the original malignant cartilage tumor. On the contrary, in other cases, imaging and gross pathology are the same as common central chondrosarcoma, only in Several limited areas on the tissue section show new malignant sarcomas.
Diagnosis
Diagnosis and differentiation of dedifferentiated chondrosarcom
The diagnosis of dedifferentiated chondrosarcoma must be particularly careful (malignant fibrous histiocytoma, osteosarcoma, high-grade fibrosarcoma), the diagnosis should be based on the patient's medical history and radiological imaging, biopsy should be performed when suspected diagnosis, sometimes, anti-differentiated chondrosarcoma Can not be diagnosed before surgery, can only be diagnosed after histological examination of the entire tumor after surgery.
