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Introduction
Introduction to brown eye disease Brownish yellow arthritis is a rare genetic disorder of amino acid metabolism. The patient's liver lacks black uric acid oxidase, which causes a large amount of black uric acid that has not been oxidatively decomposed to be excreted in the urine and deposited in various tissues and organs of the human body. . If black uric acid is deposited in the joint structure, browning arthritis is caused. basic knowledge The proportion of sickness: 0.01% Susceptible people: no specific population Mode of infection: non-infectious Complications: bone hyperplasia prostate stones
Cause
Cause of brownish arthritis
Pigmentation (30%):
Browning disease is a rare genetic disorder of amino acid metabolism. Usually, the disease can have a family history. The incidence rate of males and females is different, about 2:1. The browning arthritis is due to pigmentation in the intervertebral disc or cartilage. , resulting in degeneration of the intervertebral disc and joint lesions, that is, brownish yellow pigmentation, deposition in the joint structure of the tissue causes browning arthritis.
Prevention
Prevention of brown eye disease
The disease is mainly caused by hereditary disease brownish yellow disease, so there is no effective preventive measures at present. In order to prevent the lesions from involving the joints and other organs, patients with brownish yellow disease should be actively controlled.
Complication
Complications of brown eye disease Complications, bone hyperplasia, prostate stones
The disease is caused by pigmentation of brownish yellow disease in the joints, so the complications are mainly caused by brownish yellow disease, pigmentation in the intervertebral disc and articular cartilage, causing the cartilage to change color, weaken elasticity, become brittle, and lose resistance to pressure, and Fragile, small broken cartilage pieces can fall into the joint cavity, and then bone hyperplasia, eventually secondary degenerative osteoarthrosis, mainly deposited in hyaline cartilage, fibrocartilage, fibrous tissue and tendon, common in Auricle, nose, articular cartilage, large intima, myocardial valve, kidney and lung, followed by sclera, cornea and intervertebral disc, male patients often also with black prostate stones.
Symptom
Symptoms of brownish-induced arthritis Common symptoms Joint tonic nails, ear cartilage... Ear, nose, cartilage into blue prostate stone hunchback black urine
After the birth of the patient, in addition to the urine oxidation and dark brown to make the diaper black, there are no other symptoms, until 20 to 30 years old due to excessive deposition of black uric acid, a series of symptoms.
The main symptoms of this disease are systemic skin, sclera, corneal pigmentation, brownish yellow, ear, nose, cartilage can turn blue, tympanic membrane grayish black, hearing often decline, uric acid deposition in the aortic valve and mitral valve The valve becomes hard and there is murmur. The male disease often combines with black prostate stones. The bone and joint changes usually first erode the spine, followed by the knee, shoulder and hip. The incidence of spondylitis is 10% to 15%, more men than women. The patient complained of low back pain, examination of the lumbar plate, lordosis disappeared, mild kyphosis deformity, posture similar to ankylosing spondylitis, progressive stiffness of the spine, degeneration of the disc, narrowing, calcification, formation of marginal callus, involvement of the intervertebral ligament Even eventually causing bony rigidity, limb joint tissue also undergoes degenerative changes due to pigmentation, loss of articular cartilage elasticity, thickening of synovial fibrosis, bone erosion and cystic changes of articular cartilage and bone compaction, hardening and The formation of osteophytes can lead to rigidity of the joints, the synovial membrane of the joints is villous hyperplasia and hyperpigmentation, and there are pigmented cartilage debris in the joint fluid.
Examine
Examination of brownish yellow arthritis
The auxiliary examination method of this disease is mainly X-ray examination, X-ray performance has prominent features, some patients precede clinical symptoms, X-ray sees spinal osteoporosis, intervertebral disc calcification, narrowing, knee, shoulder, hip and other joint space narrowing Subchondral bone sclerosis, cystic cavity formation, meniscus calcification, osteochondral free body, marginal callus and tendon calcification, etc. Browning disease is different from rheumatoid arthritis, usually does not involve the small joints of the hands and feet.
Diagnosis
Diagnosis and diagnosis of brownish yellow arthritis
diagnosis
Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.
Differential diagnosis
Because the peripheral joint disease of this disease occurs later in brown yellow disease, involving large joints, and there is no difference in radiological signs and osteoarthritis, so clinical attention should be paid to rheumatoid arthritis, ankylosing spine. Identification of inflammation and gout, for some patients with disc calcification or valvular calcification, also to identify the corresponding disease, urinary acid positive positive support the diagnosis of brown huang disease.
