Chronic mucocutaneous candidiasis
Introduction
Introduction to chronic skin mucosal candidiasis Chronic mucocutaneous candidiasis is a bacterial immunodeficiency disease of persistent Candida infections of the skin, mucous membranes, hair and nails. This disease is different from other cellular immunodeficiency diseases. It only has a lack of response to Candida albicans and a small number of antigen-related fungi, but it is normal to viruses, bacteria and other microorganisms. This disease is a syndrome of some diseases and can be combined with various diseases. Endocrine organ dysfunction, tumors and other chronic debilitating diseases can also occur during the application of immunosuppressive agents. basic knowledge The proportion of illness: 0.015% Susceptible people: no specific population Mode of transmission: mother-to-child transmission Complications: hepatitis
Cause
Causes of chronic skin mucosal candidiasis
The disease is a cellular immunodeficiency disease characterized by intractable Candida infection of mucous membranes, scalp, skin and nails, and often accompanied by endocrine diseases, especially hypoparathyroidism and adrenal insufficiency, is an autosomal recessive genetic disease. .
Prevention
Chronic cutaneous mucosal candidiasis prevention
1, often clean, change underwear frequently, keep the local dry.
2, to avoid topical steroid hormones, bath shower, avoid bathing.
3. Check the patient's spouse or sexual partner, avoid treatment, and avoid sex during treatment.
Complication
Complications of chronic skin mucosal candidiasis Complications
Common complications of this disease:
1. Hepatitis.
2. Chronic lung disease.
3. Some people may involve the endocrine system, such as hypoparathyroidism.
Symptom
Symptoms of chronic skin mucosal candidiasis Common symptoms Mucosa slightly pale ovarian dysfunction squamous anemia A malnutrition Diabetes Lung infection Alopecia
It occurs mostly in women, and can occur at any age. Infants often have persistent thrush. The lesions are light and dry, only involving nails, heavy skin, mucous membranes and hair, skin scaly, eczema; mucous membranes with Candida adhesion white spots; Nail malnutrition or hyperkeratosis, chronic esophageal candidiasis can cause stenosis, and can be associated with sinus and lung infections, children with growth and development disorders, the elderly are generally lighter.
Another type is juvenile familial polyendocrine syndrome with beaded disease, except for mild to moderate candidiasis, which usually has hypothyroidism, hypoparathyroidism, Addison disease or several years after the onset of Candida. Diabetes, usually, can detect the autoantibodies of the affected endocrine organs, in addition, it can be complicated by ovarian dysfunction, pernicious anemia, alopecia and chronic active hepatitis.
Examine
Examination of chronic skin mucosal candidiasis
The immunodeficiency of this disease is not the same. The most prominent abnormality is that the skin is not reactive to Candida. The anti-candida antigenic proliferative response is absent and the lymphokine inhibitory factor inhibits the synthesis reaction, while anti-candida and other antigens The antibody response is normal, the immunoglobulin content is normal or increased; the T cell and B cell counts are generally normal, but the monocyte function is reduced.
Diagnosis
Diagnosis and diagnosis of chronic skin mucosal candidiasis
It can be diagnosed according to clinical and laboratory tests.
The disease needs to be differentiated from other cellular immunodeficiency diseases. The disease only responds to Candida albicans and a small number of antigen-related fungi, while the immunity to viruses, bacteria and other microorganisms is normal.
