late-onset hypogammaglobulinemia
Introduction
Introduction to delayed hypogamma Delayed hypogammacytosis is a condition involving a group of gamma globulin imbalances characterized by a very low or lack of certain Ig in the blood of the patient, while another Ig may increase; or the Ig content is normal and functional Normal and many other conditions. The patient's Ig deficiency content can also change over time. The common immunodeficiency is that B cells cannot synthesize certain Ig, or can only synthesize Ig with abnormal function. The number of B cells in the peripheral blood of patients is reduced or normal, but the maturation and differentiation of B cells are visceral defects or T cell immune regulation disorders. basic knowledge The proportion of illness: 0.0003% Susceptible people: no specific people Mode of infection: non-infectious complication:
Cause
The cause of delayed hypogammaglobemia
Some Ig levels in the blood are extremely low or absent, while another Ig may increase; or Ig content is normal and dysfunction, etc., the patient's Ig defect content can also change over time, the common immune defect It is B cells that cannot synthesize certain Ig, or can only synthesize Ig with abnormal function. The number of B cells in peripheral blood of patients is reduced or normal, but the maturation of B cells, differentiation of viscera in defects or T cell immune regulation disorders.
Prevention
Delayed hypogammaglobulin prevention
The key to preventing this disease is to find early treatment of the primary disease.
Complication
Delayed hypogammaglobulin complications Complication
A common complication of this disease is infection.
Symptom
Delayed hypogammaglobulitis symptoms common symptoms granulocytopenia pernicious anemia malabsorption syndrome
Late onset, more common in children and young adults, no gender differences, patients with infection is slightly lower than congenital gamma globulin deficiency, mostly chronic infection process, the most common recurrent purulent respiratory infection, more See chronic sinusitis, chronic pneumonia, etc., some patients (lack of IgA) with malabsorption syndrome, and often have intestinal blue giardia flagellosis, in addition, patients may be associated with autoimmune thyroiditis, granules The size of the tonsils and lymph nodes, such as cytopenia, pernicious anemia, rheumatoid arthritis, etc., can be normal, lymphatic follicles can be found in the lymph nodes, and the spleen often increases.
Examine
Examination of delayed hypogammaglobemia
1. Serum immunoglobulin IgG, IgA, IgM content is abnormal.
2. B cell values are often normal.
3. Some patients have a decrease in cellular immune function.
Diagnosis
Diagnosis and differential diagnosis of delayed hypogamma
The diagnosis of this disease is clear and does not need to be identified with other diseases.
