idiopathic hypereosinophilic syndrome
Introduction
Introduction to idiopathic hypereosinophilic syndrome Idiopathic hypereosinophilic syndrome is a group of unexplained eosinophilic diseases, including eosinophilic endocarditis. It is an allergic disease. Due to the extensive infiltration of eosinophils in the diseased tissue, approximately 80% of patients have an increase in eosinophils in the surrounding blood, and approximately 50% of patients have a history of personal or family allergies. basic knowledge The proportion of the disease: the incidence rate is about 0.001% -0.005% Susceptible people: no specific population Mode of infection: non-infectious Complications: heart failure
Cause
Idiopathic hypereosinophilic syndrome
The etiology has not been known so far, and it is considered to be an allergic disease. Due to the extensive infiltration of eosinophils in the diseased tissues, about 80% of patients have eosinophilia in the surrounding blood, and about 50% of patients have individuals or families. The history of allergies, so the disease may be caused by internal or external allergens, systemic or local allergic reactions, serum IgG, IgA increased, also indicated that there is immune response.
Prevention
Idiopathic hypereosinophilic syndrome prevention
The main health measure is to prevent complications.
Complication
Idiopathic hypereosinophilic syndrome complications Complications heart failure
Common complications of this disease:
1. Invasive cardiomyopathy; 2. Valvular damage; 3. Heart failure; 4. Left ventricular mitral thrombosis; 5. Temporary ischemic lesions.
Symptom
Idiopathic hypereosinophilic syndrome symptoms Common symptoms Chest pain Skin itching, urgency, night sweats, weight loss, fatigue
1. General symptoms: often have fever, fatigue, night sweats, anemia, persistent cough, chest pain, itchy skin, weight loss, shortness of breath and other symptoms.
2. The performance of eosinophilic infiltration of various organs: can involve the heart, lung, central, nervous system and hematopoietic system, and the clinical symptoms and signs of response.
Examine
Examination of idiopathic hypereosinophilic syndrome
Laboratory examination: Most patients have eosinophilia in peripheral blood. The absolute count of eosinophils in patients with mucosal lesions and myometrial lesions is (1~2)×109/L, with serosal layer. When the lesions were predominant, the average was 8×109/L, often accompanied by iron deficiency anemia. The fecal occult blood was more positive. A large number of Charcot-Leyden crystals were seen, and the ESR increased, plasma albumin decreased, and blood IgE and IgG increased.
Diagnosis
Diagnosis and differentiation of idiopathic hypereosinophilic syndrome
Diagnostic criteria
1. Continuous eosinophilic increase > 1.5 × 109 / L for more than half a year;
2. No other causes of eosinophilia were found;
3. There is evidence of multiple system organ involvement.
Differential diagnosis
1. Secondary peripheral blood eosinophilia: causes many causes of peripheral blood eosinophilia, such as allergies, parasitic infections, chemical factors, Hodgkin's disease, cystic rupture of cysticercosis, etc. However, each has its own special performance, and it can often be diagnosed with reference to certain laboratory tests.
2. Crohn's disease: This disease may have nausea, vomiting, abdominal pain, diarrhea, especially when the X-ray shows mucosal edema, thickening of the intestinal wall is ileocolitis, should be identified with Crohn's disease, peripheral blood eosinophilia It suggests eosinophilic gastroenteritis; the presence of fistula in the intestine, the presence of stenosis or secondary manifestations of intestinal inflammatory disease (stomatitis, arthritis, etc.) suggest Crohn1 disease.
3. High eosinophilic syndrome: high eosinophilic syndrome, except for elevated eosinophils in the peripheral blood, is also associated with multiple system involvement, such as heart, brain, kidney, lung and skin, can also be involved In the gastrointestinal tract, a wide range of gastrointestinal eosinophilic infiltration occurs, and the course of the disease is short and the prognosis is poor. Therefore, if there is obvious clinical manifestation of organ involvement other than the gastrointestinal tract, the syndrome should be considered.
