Bone marrow tuberculosis anemia
Introduction
Introduction to myeloid anemia Myeloid anemia is anemia caused by abnormal or non-hematopoietic cell infiltration and replacement of normal bone marrow. This type of anemia is characterized by normal pigmentation, uneven size of red blood cells on blood smears, and heterogeneous red blood cells and nucleated red blood cells. Immature granulocytes can also be seen. These changes can occur when the bone marrow is replaced by an invasive cancer, a granulomatous or lipid-depositing lesion, or a myelofibrosis. basic knowledge Proportion of disease: low incidence, about 0.001% Susceptible people: no specific population Mode of infection: non-infectious Complications: achondroplasia
Cause
Causes of myeloid anemia
There have been hypotheses that this anemia is the result of a decrease in the number of functional hematopoietic tissues, metabolic defects associated with underlying diseases, and other factors such as phagocytic erythrocyte effects in some cases have also been considered to be associated with the disease, but have never been confirmed .
The most common cause is the metastasis of cancer from the primary site to the bone marrow (the more common primary site is the breast, prostate, less kidney, lung, adrenal gland or thyroid), myeloproliferative diseases (such as late red, slow) Myeloid leukemia can also be seen in all these cases, but true myelofibrosis is the response of fibers to other intramedullary hematopoietic damage in the absence of stem cells. A rare cause of this disease is Albers-Schnberg disease.
Prevention
Myeloid anemia prevention
The key to preventing this disease is early detection and early treatment of the primary disease.
Complication
Bone marrow anemia complications Complications, achondroplasia
A common complication of this disease is that children's physical development is limited.
Symptom
Symptoms of myeloid anemia, common symptoms, splenomegaly, fatigue, low heat, fatigue, night sweats, low fever, hepatomegaly
Anemia, fatigue, hepatomegaly, splenomegaly, etc.
Examine
Examination of myeloid anemia
Anemia is usually moderately severe, characterized by positive cell, but may also be slightly cellular, erythrocyte hematopoietic assay results are normal, or may increase in some cases, red blood cell life is often shortened, in morphology, size and shape The differences are large; peripheral blood nucleated red blood cells (mostly young red blood cells) and immature white blood cells are more common, and young white erythrocytosis is used to refer to the appearance of such cells, which may be caused by rupture of the sinusoids of the bone marrow. The release of mature cells may also be caused by extramedullary hematopoiesis. There are often neutropenia and reticulosis, and reticulosis may be premature release of reticulocytes from the bone marrow or extramedullary space. What is caused is not necessarily a sign of increased blood cell regeneration, white blood cell counts can be normal, reduced or increased, platelet counts are often low, and large deformed platelets may be seen.
The kinetic study using tracer iron can show hematopoietic activity in the liver and spleen. The bone marrow is often dry and the results are different depending on the underlying disease. A bone marrow circumcision biopsy is usually needed to confirm the diagnosis.
X-ray examination revealed bone lesions (osteoblastic sclerosis) characterized by persistent myelofibrosis or other bone changes (ie, osteogenic and osteolytic lesions of the tumor) that may indicate the cause of anemia.
Diagnosis
Diagnosis and diagnosis of myeloid anemia
diagnosis
Diagnosis is based on clinical performance and examination.
Differential diagnosis
Mainly differentiated from anemia caused by other causes.
