Urine copper

Adults contain about 100-200 mg of copper, which is widely distributed in various organs. The liver content is the highest, accounting for about 20% of the total body, followed by the brain and kidney. Plasma copper 95% binds to α2 globulin and is blue, so it is called ceruloplasmin. Each molecule of ceruloplasmin binds to 8 copper atoms and the binding is firm. The ceruloplasmin contains about 3% of the total copper content in the body. Other copper in plasma is loosely bound to plasma albumin, and only a few are in a free state. In vivo copper acts mainly as a cofactor for various enzymes such as superoxide dismutase and cytochrome oxidase. Adults consume about 2 to 2.5 mg of copper per day from food, and nearly half of them are absorbed to maintain copper loss in the body. The main route of excretion of copper in the body is the bile duct, and the amount of urine is very small. The atomic weight of Cu is 63.54. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: normal. Normal value: Urinary copper: 0.24-0.48μmol/24h Above normal: Hepatolenticular degeneration, intrahepatic or extrahepatic cholestasis, biliary cirrhosis, chronic active hepatitis, after the use of penicillamine. negative: Positive: Tips: Try to use fresh morning urine when doing this check. The urine that is randomly selected is preferably mid-stage urine. Menstrual women are not suitable for this examination. Normal value 0.24 to 0.48 μmol/24 h (15 to 30 μg/24 h). Clinical significance Increase hepatolenticular degeneration, intrahepatic or extrahepatic cholestasis, biliary cirrhosis, chronic active hepatitis, after the use of penicillamine. High results may be diseases: hepatolenticular degeneration, pediatric hepatolenticular degeneration, hemolytic anemia caused by copper poisoning, pediatric hepatitis D virus, pediatric sclerosing cholangitis, primary sclerosing cholangitis, hepatitis B attention matter Note during inspection: Fresh morning urine should be used as much as possible during this examination. The urine that is randomly selected is preferably mid-stage urine. Not suitable for the crowd: menstrual women. Inspection process Inspection process: As with routine urine tests, use a clean, dry container with a disposable urine cup and urine test tube provided by the hospital. Take about 10 ml of urine and send it to the designated inspection window of the hospital, then use the isotope method and microscopy. Not suitable for the crowd Menstrual women. Adverse reactions and risks no.