Uroporphyrin

Porphyrins are intermediates in the synthesis of bilirubin in the body. Due to a certain genetic abnormality, the human body produces too much porphyrin, causing hematoporphyrin disease, which is metabolized in the body to produce uroporphyrin and coproporphyrin, which are excreted by urine or feces. When urinary porphyrins appear in the urine, the urine turns red; it may also be colorless, but may appear red when exposed to sunlight or acidified and boiled. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Found in congenital porphyria, delayed cutaneous porphyria (onset), acute porphyria (onset), lead and heavy metal poisoning, liver disease and some hemolytic anemia, myocardial infarction. Tips: In order to avoid decomposition of porphyrin, brown specimens should be used for specimens, fresh urine should be sent in time, and porphyrin-rich foods or drugs should be banned before urine testing. Normal value negative. Clinical significance Positive in congenital porphyria, delayed cutaneous porphyria (onset), acute porphyria (onset), lead and heavy metal poisoning, liver disease and some hemolytic anemia, myocardial infarction. Positive results may be diseases: congenital light-sensitive porphyria in children, porphyria, porcine acute intermittent porphyria, hematoporphyria, hepatic porphyria syndrome, mud snail-solar dermatitis, red blood cells Precursor porphyria considerations (1) In order to avoid decomposition of porphyrin, the specimen should be kept in brown bottles and fresh urine should be sent in time. (2) Disable porphyrin-rich foods or drugs before urine testing. Inspection process Add 5 ml of urine to the stoppered glass tube, add 3 ml of reagent, add stopper, shake well, let stand for a while, and then stratify the urine and ethyl acetate, then irradiate the upper layer extract with ultraviolet light to observe the presence or absence of red fluorescence. . Not suitable for the crowd Generally no taboos. Adverse reactions and risks No.